Enteroviral infections in the first three months of life
Open accessAbstract
Enteroviruses (EVs) are an important source of infection in the paediatric age, with most cases concerning the neonatal age and early infancy. Molecular epidemiology is crucial to understand the circulation of main serotypes in a specific area and period due to their extreme epidemiological variability. The diagnosis of EVs infection currently relies on the detection of EVs RNA in biological samples (usually cerebrospinal fluid and plasma, but also throat swabs and feces) through a polymerase chain reaction assay. Although EVs infections usually have a benign course, they sometimes become life threatening, especially when symptoms develop in the first few days of life. Mortality is primarily associated with myocarditis, acute hepatitis, and multi-organ failure. Neurodevelopmental sequelae have been reported following severe infections with central nervous system involvement. Unfortunately, at present, the treatment of EVs infections is mainly supportive. The use of specific antiviral agents in severe neonatal infections has been reported in single cases or studies including few neonates. Therefore, further studies are needed to confirm the efficacy of these drugs in clinical practice.
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Globally, EVs are responsible for nearly 85% of viral meningoencephalitis cases.
“Globally, EVs are responsible for nearly 85% of viral meningoencephalitis cases15.”
From Clinical Impact of Cerebrospinal Fluid Multiplex Polymerase Chain Reaction (PCR) Testing in Children with Suspected Central Nervous System Infection (2025) · cites this paper as [15]
Section 4.2.2 says non-polio EVs account for 85–95% of viral meningitis cases in which an etiologic agent is identified. It does not give that figure for meningoencephalitis globally; the same section reports a different figure, 10–20%, for encephalitis with an identified cause. (LLM, conf=0.88)
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References 100 · Cited by 34
Research works printed but not linked: 1
- [3]Cherry J.D. Krogstad P. Enterovirus, Parechovirus and Saffold Virus Infections Remington and Klein’s Infectious Diseases of the Fetus and Newborn Infant Elsevier Health Sciences Amsterdam, The Netherlands 2015 978-0-323-24147-2
- Authors
- Sandoni, M., Ciardo, L., Tamburini, C., Boncompagni, A., Rossi, C., Guidotti, I., Garetti, E., Lugli, L., Iughetti, L., & Berardi, A.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Lugli, Licia
- Venue
- Pathogens
- Publisher
- MDPI AG
- Published
- 2022-01-03
- Volume
- 11
- Issue
- 1
- Pages
- 60
- ISSN
- 2076-0817 (ISSN-L)
- PMC
- PMC8782040
- OpenAlex
- W4205427314
- Cited by
- 34
- References
- 100
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 11 · 2023: 11 · 2022: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pathogens (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Literature Analysis and Criticism
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- enterovirus infection, neonatal infection, early infancy, molecular epidemiology, enterovirus serotypes, myocarditis, acute hepatitis, multiple organ failure, neurodevelopmental sequelae, antiviral therapy, supportive therapy
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