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Cited by 322Electrospun Nanofibers in Biomedical ApplicationsSilk-based biomaterials and applicationsNanoparticle-Based Drug Delivery

Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery

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Bhattarai, Rajan Sharma, Bachu, Rinda Devi, Boddu, Sai H. S., Bhaduri, Sarit·2018·Pharmaceutics
DOI 10.3390/pharmaceutics11010005PMC PMC6358861
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Abstract

The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties can also be modified by polarity inversion and by varying the collector design. The active moiety is incorporated into polymeric fibers by blending, surface modification or emulsion formation. The nanofibers can be further modified to deliver multiple drugs, and multilayer polymer coating allows sustained release of the incorporated active moiety. Electrospun nanofibers prepared from polymers are used to deliver antibiotic and anticancer agents, DNA, RNA, proteins and growth factors. This review provides a compilation of studies involving the use of electrospun fibers in biomedical applications with emphasis on nanoparticle-impregnated nanofibers.

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Cited by

Sorted by citations

Authors
Bhattarai, R. S., Bachu, R. D., Boddu, S. H. S., & Bhaduri, S.
Affiliations
  • University of Toledo (US)
  • Ajman University (AE)
Corresponding author
Boddu, Sai H. S.
ORCID
Venue
Pharmaceutics
Publisher
MDPI AG
Published
2018-12-24
Volume
11
Issue
1
Pages
5
ISSN
1999-4923 (ISSN-L)
DOI
10.3390/pharmaceutics11010005
PMC
PMC6358861
OpenAlex
W2905930064
Cited by
322
References
1
Citations by year
2026: 35 · 2025: 34 · 2024: 44 · 2023: 43 · 2022: 45 · 2021: 56 · 2020: 41 · 2019: 24
FWCI
1.99
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmaceutics (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Toledo
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
electrospun nanofibers, drug delivery, nanoparticle delivery, electrospinning parameters, coaxial electrospinning, polarity reversal, collector design, sustained drug release, antibiotic delivery, anticancer agents, growth factor delivery, protein delivery

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