Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy
Open accessAbstract
Centella asiatica, widely known as Gotu kola, is a traditional herb celebrated for its benefits in skin health and wound healing. Recent research has provided new insights into its efficacy, particularly through topical applications. This review highlights the plant’s mechanisms, focusing on its active compounds such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, which enhance collagen synthesis, modulate inflammation, and offer antioxidant protection. Clinical trials have been collected and summarized that innovative delivery systems, such as hydrogels, nanostructures or microneedles, can accelerate wound healing, reduce wound size, and improve recovery times in various wound types, including diabetic ulcers and burns. Future research will likely refine these technologies and explore new applications, reinforcing the role of C. asiatica in contemporary wound care. Advances in formulation and delivery will continue to enhance the plant’s therapeutic potential, offering promising solutions for effective wound management.
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Recent experimental studies have demonstrated that asiaticoside and madecassoside can stimulate fibroblast proliferation and collagen synthesis, contributing to dermal matrix remodeling.
“Recent experimental studies have demonstrated that asiaticoside and madecassoside can stimulate fibroblast proliferation and collagen synthesis, contributing to dermal matrix remodeling [18,39,40].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [18]
Section 2.1 (page unavailable) says asiaticoside stimulates collagen synthesis and enhances fibroblast proliferation, supporting that part of the claim. The paper discusses madecassoside in a combined extract in Section 4 (page unavailable), but does not establish that madecassoside itself stimulates fibroblast proliferation or collagen synthesis. Dermal matrix remodeling is a reasonable interpretation of the asiaticoside findings, not an outcome the cited passages establish for both compounds. (LLM, conf=0.87)
Experimental — accuracy not yet measuredTriterpenoid constituents have been shown to enhance antioxidant defense systems, mitigate oxidative stress-induced skin damage, modulate inflammatory pathways, and support epidermal barrier integrity.
“In addition, triterpenoid constituents have been shown to enhance antioxidant defense systems and mitigate oxidative stress-induced skin damage, as well as modulate inflammatory pathways and support epidermal barrier integrity [18,39,40].”
From A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. (2026) · cites this paper as [18]
Section 2.4 (page unavailable) attributes anti-inflammatory effects to triterpenoid saponins and describes asiatic acid regulating catalase and superoxide dismutase. Section 2.3 reports antioxidant activity for Centella asiatica extracts, but emphasizes phenolic constituents rather than showing that triterpenoids enhance antioxidant defenses or prevent oxidative skin damage. Section 3.1 reports improved skin hydration from formulations containing the extract, not that triterpenoids themselves support epidermal barrier integrity. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCentella asiatica is a medicinal plant traditionally used in Asian and Ayurvedic medicine for wound healing and various skin disorders.
“Centella asiatica (L.) Urb. is a medicinal plant traditionally used in Asian and Ayurvedic medicine for wound healing and various skin disorders [16,17,18].”
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References 39 · Cited by 78
Research works printed but not linked: 1
- [14]Mushtaq A. Qayyum A. Chemistry, traditional uses and pharmacological effects of Centella asiatica (L.): A review Int. J. Chem. Biochem. Sci. 2018 14 104 109
- Authors
- Witkowska, K., Paczkowska-Walendowska, M., Garbiec, E., & Cielecka-Piontek, J.
- Affiliations
- Poznan University of Medical Sciences (PL)
- Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2024-09-26
- Volume
- 16
- Issue
- 10
- Pages
- 1252
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC11510310
- OpenAlex
- W4402864502
- Cited by
- 78
- References
- 39
- Citations by year
- 2026: 44 · 2025: 33
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Science Center (Poland) (2020/39/D/NZ7/01824)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Centella asiatica, wound healing, topical application, asiaticoside, madecassoside, asiatic acid, madecassic acid, collagen synthesis, anti-inflammatory activity, antioxidant activity, hydrogels, nanostructures, microneedles, diabetic ulcers, burns, wound care
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