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Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment

Herdiana, Yedi, Wathoni, Nasrul, Shamsuddin, Shaharum, Joni, I Made, Muchtaridi, Muchtaridi·2021·Polymers
DOI 10.3390/polym13111717PMC PMC8197416
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Abstract

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

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Figure 1 Types of NPs for targeted DDS used in BC research.
Figure 1 Types of NPs for targeted DDS used in BC research.CC BY · PubMed Central
Figure 2 Schematic illustration of target-drug chitosan nanopolymer.
Figure 2 Schematic illustration of target-drug chitosan nanopolymer.CC BY · PubMed Central
Figure 3 Ligan for active targeting.
Figure 3 Ligan for active targeting.CC BY · PubMed Central
Figure 4 Preparing method of chitosan nanoparticles.
Figure 4 Preparing method of chitosan nanoparticles.CC BY · PubMed Central
Figure 5 Chitosan structural features and their impacts on chitosan-based nanoparticles.
Figure 5 Chitosan structural features and their impacts on chitosan-based nanoparticles.CC BY · PubMed Central
Figure 6 Passive and Active Targeting in ChNPs.
Figure 6 Passive and Active Targeting in ChNPs.CC BY · PubMed Central

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Research works printed but not linked: 126

  1. Fathi, 2019, Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly(N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer, Int. J. Biol. Macromol., 128, 957, 10.1016/j.ijbiomac.2019.01.122 · DOI · Paper page
  2. Mirza, 2021, Nanoparticles-based drug delivery and gene therapy for breast cancer: Recent advancements and future challenges, Semin. Cancer Biol., 69, 226, 10.1016/j.semcancer.2019.10.020 · DOI
  3. Mostafa, 2019, Design and synthesis of 2-phenyl benzimidazole derivatives as VEGFR-2 inhibitors with anti-breast cancer activity, Chem. Biol. Drug Des., 93, 454, 10.1111/cbdd.13433 · DOI
  4. Shanmuganathan, 2019, Chitosan nanopolymers: An overview of drug delivery against cancer, Int. J. Biol. Macromol., 130, 727, 10.1016/j.ijbiomac.2019.02.060 · DOI
  5. Taher, 2013, Microencapsulation of alpha-mangostin into PLGA microspheres and optimization using response surface methodology intended for pulmonary delivery, J. Microencapsul., 30, 728, 10.3109/02652048.2013.788081 · DOI
  6. Liyanage, 2019, Nanoparticle-mediated targeted drug delivery for breast cancer treatment, Biochim. Biophys. Acta Rev. Cancer, 1871, 419, 10.1016/j.bbcan.2019.04.006 · DOI
  7. Chimplee, 2019, Anti-breast cancer potential of frullanolide from Grangea maderaspatana plant by inducing apoptosis, Oncol. Lett., 17, 5283
  8. Afzal, 2021, Nanomedicine in treatment of breast cancer—A challenge to conventional therapy, Semin. Cancer Biol., 69, 279, 10.1016/j.semcancer.2019.12.016 · DOI
  9. Mojeiko, 2019, Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer, Int. J. Pharm., 560, 365, 10.1016/j.ijpharm.2019.02.011 · DOI
  10. Din, 2017, Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors, Int. J. Nanomed., 12, 7291, 10.2147/IJN.S146315 · DOI
  11. Huang, L., Huang, J., Huang, J., Xue, H., Liang, Z., Wu, J., and Chen, C. (2020). Nanomedicine—A promising therapy for hematological malignancies. Biomater. Sci., 1–34. · DOI
  12. Yetisgin, A.A., Cetinel, S., Zuvin, M., Kosar, A., and Kutlu, O. (2020). Therapeutic Nanoparticles and Their Targeted Delivery Applications. Molecules, 25. · DOI
  13. Navya, P.N., Kaphle, A., Srinivas, S.P., Bhargava, S.K., Rotello, V.M., and Daima, H.K. (2019). Current trends and challenges in cancer management and therapy using designer nanomaterials. Nano Converg., 6. · DOI
  14. Dang, 2020, Nanoparticle-based drug delivery systems for cancer therapy, Smart Mater. Med., 1, 10, 10.1016/j.smaim.2020.04.001 · DOI
  15. Okamatsu, 2013, Folate-appended β-cyclodextrin as a promising tumor targeting carrier for antitumor drugs in vitro and in vivo, Bioconjug. Chem., 24, 724, 10.1021/bc400015r · DOI
  16. Qandil, 2018, Depolymerization of HMW into a predicted LMW chitosan and determination of the degree of deacetylation to guarantee its quality for research use, J. Excip. Food Chem., 9, 1
  17. Wathoni, 2019, Formulation and Characterization of α -Mangostin in Chitosan Nanoparticles Coated by Sodium Alginate, Sodium Silicate, and Polyethylene Glycol, J. Pharm. Bioallied Sci., 11, 1, 10.4103/jpbs.JPBS_206_19 · DOI
  18. Phunpee, 2018, Controllable encapsulation of α-mangostin with quaternized β-cyclodextrin grafted chitosan using high shear mixing, Int. J. Pharm., 538, 21, 10.1016/j.ijpharm.2017.12.016 · DOI
  19. Wathoni, 2020, Nanoparticle drug delivery systems for α-mangostin, Nanotechnol. Sci. Appl., 13, 23, 10.2147/NSA.S243017 · DOI
  20. Sun, 2019, Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer, Front. Oncol., 9, 1, 10.3389/fonc.2019.01153 · DOI
  21. Patra, J.K., Das, G., Fraceto, L.F., Vangelie, E., Campos, R., Rodriguez, P., Acosta, L.S., Diaz, L.A.D., Grillo, R., and Swamy, M.K. (2018). Nano based drug delivery systems: Recent developments and future prospects. J. Nanobiotechnol., 1–33. · DOI
  22. Zubair, H., Azim, S., Ahmad, A., Khan, M.A., Patel, G.K., Singh, S., and Singh, A.P. (2017). Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch. Molecules, 22. · DOI
  23. Taghavi, 2017, Chitosan-modified PLGA nanoparticles tagged with 5TR1 aptamer for in vivo tumor-targeted drug delivery, Cancer Lett., 400, 1, 10.1016/j.canlet.2017.04.008 · DOI
  24. Sun, L., Wu, Q., Peng, F., Liu, L., and Gong, C. (2015). Strategies of polymeric nanoparticles for enhanced internalization in cancer therapy. Colloids Surfaces B Biointerfaces. · DOI
  25. Truffi, M., Mazzucchelli, S., Bonizzi, A., Sorrentino, L., Allevi, R., Vanna, R., Morasso, C., and Fabio Corsi, F. (2019). Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy. Int. J. Mol. Sci., 20. · DOI
  26. Wang, 2018, Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review, Int. J. Pharm., 535, 253, 10.1016/j.ijpharm.2017.11.003 · DOI
  27. Allahverdiyev, 2018, Current aspects in treatment of breast cancer based of nanodrug delivery systems and future prospects, Artif. Cells Nanomed. Biotechnol., 46, S755, 10.1080/21691401.2018.1511573 · DOI
  28. Siddique, S., and Chow, J.C.L. (2020). Application of Nanomaterials in Biomedical Imaging and Cancer Therapy. Nanomaterials, 10. · DOI
  29. Dhanashekaran, 2014, Polymeric Nanoparticles- the new face in Drug Delivery and Cancer Therapy, Malaya J. Biosci., 1, 1
  30. Silva, 2020, Polymeric NanopPolymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology, Molecules, 25, 3731, 10.3390/molecules25163731 · DOI · Paper page
  31. Hoosain, 2015, Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia Therapy, Biomed. Res. Int., 2015, 1, 10.1155/2015/484963 · DOI
  32. Li, 2016, Enhanced Cellular Internalization and On-Demand Intracellular Release of Doxorubicin by Stepwise pH-/Reduction-Responsive Nanoparticles, ACS Appl. Mater. Interfaces, 8, 32146, 10.1021/acsami.6b09604 · DOI
  33. Yoo, J., Park, C., Yi, G., Lee, D., and Koo, H. (2019). Active Targeting Strategies Using Biological Ligands for Nanoparticle Drug Delivery Systems. Cancers, 11. · DOI
  34. Sen, 2020, Materials Advances Nanoparticle mediated alteration of EMT dynamics: An approach to modulate, Mater. Adv., 1, 2614, 10.1039/D0MA00455C · DOI · Paper page
  35. Pazzini, 2019, Complete Disaggregation of MCF-7-derived Breast Tumour Spheroids with Very Low Concentrations of α -Mangostin Loaded in CD44 Thioaptamer-tagged Nanoparticles, Int. J. Med. Sci., 16, 33, 10.7150/ijms.28135 · DOI · Paper page
  36. Zhang, 2019, Advances in chitosan-based nanoparticles for oncotherapy, Carbohydr. Polym., 222, 115004, 10.1016/j.carbpol.2019.115004 · DOI
  37. Wathoni, N., Yuniarsih, N., Cahyanto, A., and Muhctaridi, M. (2019). α-Mangostin Hydrogel Film Based Chitosan—Alginate for Recurrent Aphthous Stomatitis. Appl. Sci., 9. · DOI
  38. Hashad, 2017, Surface functionalization of methotrexate-loaded chitosan nanoparticles with hyaluronic acid/human serum albumin: Comparative characterization and in vitro cytotoxicity, Int. J. Pharm., 522, 128, 10.1016/j.ijpharm.2017.03.008 · DOI
  39. Shariatinia, 2019, Pharmaceutical applications of chitosan, Adv. Colloid. Interface Sci., 263, 131, 10.1016/j.cis.2018.11.008 · DOI
  40. Aljebory, 2017, Chitosan Nanoparticles: Review Article, Imp. J. Interdiscip Res., 3, 233
  41. Onyebuchi, 2019, Chitosan And N, N, N-Trimethyl Chitosan Nanoparticle Encapsulation of Ocimum Gratissimum Essential Oil: Optimised Synthesis, In Vitro Release and Bioactivity, Int. J. Nanomed., 14, 7707, 10.2147/IJN.S220202 · DOI
  42. Maiyo, F., and Singh, M. (2019). Folate-Targeted mRNA Delivery Using Chitosan-Functionalized Selenium Nanoparticles: Potential in Cancer Immunotherapy. Pharmaceuticals, 12. · DOI
  43. Niu, 2019, A chitosan-based cascade-responsive drug delivery system for triple-negative breast cancer therapy, J. Nanobiotechnol., 17, 95, 10.1186/s12951-019-0529-4 · DOI
  44. Ahmed, 2016, Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery, Drug Des. Devel. Ther., 10, 483, 10.2147/DDDT.S99651 · DOI
  45. Quiñones, J.P., Peniche, H., and Peniche, C. (2018). Chitosan Based Self-Assembled Nanoparticles in Drug Delivery. Polymers, 10. · DOI
  46. Palmeira, 2020, Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems, Int. J. Biol. Macromol., 159, 804, 10.1016/j.ijbiomac.2020.05.104 · DOI
  47. Ahmed, 2015, Chitosan & its derivatives: A review in recent innovations, IJPSR, 6, 14
  48. Bharathiraja, 2018, Multimodal tumor-homing chitosan oligosaccharide-coated biocompatible palladium nanoparticles for photo-based imaging and therapy, Sci. Rep., 8, 500, 10.1038/s41598-017-18966-8 · DOI
  49. Yin, J.J., Sharma, S., Shumyak, S.P., Wang, Z.X., Zhou, Z.W., Zhang, Y., Guo, P., Li, C., Yang, T., and Kanwar, G.R. (2013). Synthesis and Biological Evaluation of Novel Folic Acid Receptor-Targeted, β-Cyclodextrin-Based Drug Complexes for Cancer Treatment. PLoS ONE, 8. · DOI
  50. Wang, W., Meng, Q., Li, Q., Liu, J., Zhou, M., Jin, Z., and Zhao, K. (2020). Chitosan Derivatives and Their Application in Biomedicine. Int. J. Mol. Sci., 21. · DOI
  51. Liberti, 2017, The Warburg Effect: How Does it Benefit Cancer Cells?, Trends Biochem. Sci., 41, 211, 10.1016/j.tibs.2015.12.001 · DOI · Paper page
  52. Lokerse, 2017, Comparing the therapeutic potential of thermosensitive liposomes and hyperthermia in two distinct subtypes of breast cancer, J. Control. Release, 258, 34, 10.1016/j.jconrel.2017.05.005 · DOI
  53. Jordan, 2015, The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer, Endocr. Relat. Cancer, 22, R1, 10.1530/ERC-14-0448 · DOI
  54. Luesakul, 2016, Shape-controlled synthesis of cubic-like selenium nanoparticles via the self-assembly method, Carbohydr. Polym., 153, 435, 10.1016/j.carbpol.2016.08.004 · DOI
  55. Bharti, 2019, Trastuzumab decorated TPGS-g-chitosan nanoparticles for targeted breast cancer therapy, Colloids Surf B Biointerfaces, 173, 366, 10.1016/j.colsurfb.2018.10.007 · DOI
  56. Carvalho, 2019, Optimization of composition and obtainment parameters of biocompatible nanoemulsions intended for intraductal administration of piplartine (piperlongumine) and mammary tissue targeting, Int. J. Pharm., 567, 118460, 10.1016/j.ijpharm.2019.118460 · DOI
  57. Hassani, 2015, Preparation of chitosan-TPP nanoparticles using microengineered membranes—Effect of parameters and encapsulation of tacrine, Colloids Surf. A Physicochem. Eng. Asp., 482, 34, 10.1016/j.colsurfa.2015.04.006 · DOI
  58. Jonassen, 2012, Effects of ionic strength on the size and compactness of chitosan nanoparticles, Colloid. Polym. Sci., 290, 919, 10.1007/s00396-012-2604-3 · DOI
  59. Rampino, 2013, Chitosan nanoparticles: Preparation, size evolution and stability, Int. J. Pharm., 455, 219, 10.1016/j.ijpharm.2013.07.034 · DOI
  60. Aaldering, 2015, Physicochemical and biological characterization of chitosan- microRNA nanocomplexes for gene delivery to MCF-7 breast cancer cells, Nat. Publ. Gr., 5, 1
  61. Gholami, N., Cohan, R.A., Razavi, A., Bigdeli, R., Dashbolaghi, A., and Asgary, V. (2019). Cytotoxic and apoptotic properties of a novel nano-toxin formulation based on biologically synthesized silver nanoparticle loaded with recombinant truncated pseudomonas exotoxin A. J. Cell Physiol. · DOI
  62. Mahidhara, 2015, Oral administration of iron-saturated bovine lactoferrin-loaded ceramic nanocapsules for breast cancer therapy and influence on iron and calcium metabolism, Int. J. Nanomed., 10, 4081
  63. Alinejad, 2016, Direct Co-delivery of IL17RB siRNA and doxorubicin by chitosan-based nanoparticles for enhanced anticancer ef fi cacy in breast cancer cells, Science, 83, 229
  64. Sun, 2019, Photoacoustic imaging of cancefr cells with glycol-chitosan-coated gold nanoparticles as contrast agents, J. Biomed. Opt., 24, 1
  65. Wang, 2019, Sequentially self-assembled polysaccharide-based nanocomplexes for combined chemotherapy and photodynamic therapy of breast cancer, Carbohydr. Polym., 203, 203, 10.1016/j.carbpol.2018.09.035 · DOI
  66. Wang, 2019, Doxorubicin/cisplatin co-loaded hyaluronic acid/chitosan-based nanoparticles for in vitro synergistic combination chemotherapy of breast cancer, Carbohydr. Polym., 225, 115206, 10.1016/j.carbpol.2019.115206 · DOI
  67. Naruphontjirakul, 2019, Development of anti-HER2-targeted doxorubicin-core-shell chitosan nanoparticles for the treatment of human breast cancer, Int. J. Nanomed., 14, 4105, 10.2147/IJN.S198552 · DOI
  68. Pertiwi, 2018, Formulation of nanoparticles ribosome inactivating proteins from Mirabilis jalapa L. (RIP MJ) conjugated AntiEpCAM antibody using low chain chitosan-pectin and cytotoxic activity against breast cancer cell line, Pak. J. Pharm. Sci., 31, 379
  69. Wicaksono, 2016, Formulation and Cytotoxicity of Ribosome-Inactivating Protein Mirabilis Jalapa, L. Nanoparticles Using Alginate-Low Viscosity Chitosan Conjugated with Anti-Epcam Antibodies in the T47D Breast Cancer Cell Line, Asian Pac. J. Cancer Prev., 17, 2277, 10.7314/APJCP.2016.17.4.2277 · DOI
  70. Kievit, 2012, Targeting of primary breast cancers and metastases in a transgenic mouse model using rationally designed multifunctional SPIONs, ACS Nano, 6, 2591, 10.1021/nn205070h · DOI
  71. David, 2018, Formulation and in vitro evaluation of a siRNA delivery nanosystem decorated with gH625 peptide for triple negative breast cancer theranosis, Eur. J. Pharm. Biopharm., 131, 99, 10.1016/j.ejpb.2018.07.024 · DOI
  72. Hou, 2019, A novel pH-sensitive targeting polysaccharide-gold nanorod conjugate for combined photothermal-chemotherapy of breast cancer, Carbohydr. Polym., 212, 334, 10.1016/j.carbpol.2019.02.045 · DOI
  73. Danaei, M., Dehghankhold, M., Ataei, S., Hasanzadeh Davarani, F., Javanmard, R., Dokhani, A., Khorasani, S., and Mozafari, M.R. (2018). Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems. Pharmaceutics, 10. · DOI
  74. Wu, 2019, Size-dependent cellular uptake and localization pro fi les of silver nanoparticles, Int. J. Nanomed., 14, 4247, 10.2147/IJN.S201107 · DOI
  75. Shafawati, 2019, The Effect of Gold Nanoparticle Size in the Cellular Uptake, Solid State Phenom., 290, 75, 10.4028/www.scientific.net/SSP.290.75 · DOI
  76. Agrawal, 2016, PEGylated chitosan nanoparticles potentiate repurposing of ormeloxifene in breast cancer therapy, Nanomedicine, 11, 2147, 10.2217/nnm-2016-0095 · DOI
  77. Chen, Y., Wu, D., Zhong, W., Kuang, S., Luo, Q., Song, L., He, L., Feng, X., and Tao, X. (2018). Evaluation of the PEG Density in the PEGylated Chitosan Nanoparticles as a Drug Carrier for Curcumin and Mitoxantrone. Nanomaterials, 8. · DOI
  78. Hu, 2017, Nanotechnology based therapeutic modality to boost anti-tumor immunity and collapse tumor defense, J. Control. Release, 256, 26, 10.1016/j.jconrel.2017.04.026 · DOI
  79. Dai, 2017, Breast Cancer Cell Line Classification and Its Relevance with Breast Tumor Subtyping, J. Cancer, 8, 3131, 10.7150/jca.18457 · DOI
  80. Raica, 2015, The Story of MCF-7 Breast Cancer Cell Line: 40 years of Experience in Research, Anticancer Res., 3154, 3147
  81. Huang, 2020, Characterization of Triple-Negative Breast Cancer MDA-MB-231 Cell Spheroid Model, Onco Targets Ther., 13, 5395, 10.2147/OTT.S249756 · DOI
  82. Boegel, 2020, Multi-Omics Characterization of the 4T1 Murine Mammary Gland Tumor Model, Front. Oncol., 10, 1
  83. Chen, 2011, Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line, Int. J. Mol. Med., 28, 985
  84. Sutradhar, 2014, Nanotechnology in Cancer Drug Delivery and Selective Targeting, ISRN Nanotechnol., 2014, 1195, 10.1155/2014/939378 · DOI · Paper page
  85. Bajwa, 2018, Recent advances in “smart” delivery systems for extended drug release in cancer therapy, Int. J. Nanomed., 13, 4727, 10.2147/IJN.S168053 · DOI
  86. Karimi, M., Ghasemi, A., Zangabad, P.S., Rahighi, R., Basri, S.M.M., Mirshekari, H., Amiri, M., Pishabad, Z.S., and Aslani, A. (2016). Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem. Soc. Rev. · DOI
  87. Amoozgar, 2012, Low Molecular-Weight Chitosan as a pH-Sensitive Stealth Coating for Tumor-Specific Drug Delivery, Mol. Pharm., 9, 1262, 10.1021/mp2005615 · DOI
  88. Madhusudhan, 2014, Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan, Int. J. Mol. Sci., 15, 8216, 10.3390/ijms15058216 · DOI
  89. Guo, 2014, Chitosan- g- TPGS Nanoparticles for Anticancer Drug Delivery and Overcoming Multidrug Resistance, Mol. Pharm., 11, 59, 10.1021/mp400514t · DOI
  90. Feng, C., Wang, Z., Jiang, C., Kong, M., Zhou, X., Li, Y., Cheng, X., and Chen, X. (2013). Chitosan/o-carboxymethyl chitosan nanoparticles for efficient and safe oral anticancer drug delivery: In vitro and in vivo evaluation. Int. J. Pharm., 1–10. · DOI
  91. Hu, 2015, Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier, J. Control. Release, 206, 91, 10.1016/j.jconrel.2015.03.018 · DOI
  92. Guerry, 2014, Redox-stimuli responsive micelles from DOX-encapsulating polycaprolactone- g -chitosan oligosaccharide, Carbohydr. Polym., 112, 746, 10.1016/j.carbpol.2014.06.052 · DOI
  93. Cavalli, 2015, Colloids and Surfaces B: Biointerfaces Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents, Colloids Surf. B Biointerfaces, 129, 39, 10.1016/j.colsurfb.2015.03.023 · DOI
  94. Srinivasan, 2013, Near-infrared fluorescing IR820-chitosan conjugate for multifunctional cancer theranostic applications, J. Photochem. Photobiol. B Biol., 119, 52, 10.1016/j.jphotobiol.2012.12.008 · DOI
  95. Zhong, S., Zhang, H., Liu, Y., Wang, G., Shi, C., Li, Z., Feng, Y., and Cui, X. (2017). Folic Acid Functionalized Reduction-Responsive Magnetic Chitosan Nanocapsules for Targeted Delivery and Triggered Release of Drugs. Carbohydr. Polym. · DOI
  96. Meng, 2013, Chitosan-Based Nanocarriers with pH and Light Dual Response for Anticancer Drug Delivery, Biomacromolecules, 4, 2601, 10.1021/bm400451v · DOI
  97. Lungu, I.I., Grumezescu, A.M., Andronescu, E., and Volceanov, A. (2019). Nanobiomaterials Used in Cancer Therapy: An up-to-date overview. Molecules, 24. · DOI
  98. Bazak, R., Houri, M., and Achy SEl Kamel, S. (2014). Cancer active targeting by nanoparticles: A comprehensive review of literature Cancer active targeting by nanoparticles: A comprehensive review of literature. J. Cancer Res. Clin. Oncol. · DOI
  99. Zhang, 2019, Dual-responsive nanoparticles based on chitosan for enhanced breast cancer therapy, Carbohydr. Polym., 221, 84, 10.1016/j.carbpol.2019.05.081 · DOI
  100. Salatin, 2017, Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles Mechanisms of nanoparticle endocytosis, J. Cell Mol. Med., 21, 1668, 10.1111/jcmm.13110 · DOI
  101. Moraru, C., Mincea, M., Menghiu, G., and Ostafe, V. (2020). Understanding the Factors Influencing Chitosan-Based Nanoparticles-Protein Corona Interaction and Drug Delivery Applications. Molecules, 25. · DOI
  102. Jedrzejczak-silicka, M., and Mijowska, E. (2018). General Cytotoxicity and Its Application in Nanomaterial Analysis. Cytotoxicity, IntechOpen. · DOI
  103. Sahu, 2016, In Vitro Cytotoxicity of Nanoparticles: A Comparison between Particle Size and Cell Type, J. Nanosci., 2016, 1, 10.1155/2016/4023852 · DOI
  104. Grijalva, M., Vallejo-lópez, M.J., Salazar, L., Camacho, J., and Kumar, B. (2018). Cytotoxic and Antiproliferative Effects of Nanomaterials on Cancer Cell Lines: A Review. Unraveling the Safety Profile of Nanoscale Particles and Materials—From Biomedical to Environmental Applications, IntechOpen. · DOI
  105. Ding, 2005, Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-Onions on Human Skin Fibroblast, Nano Lett., 5, 2448, 10.1021/nl051748o · DOI · Paper page
  106. Chivere, V.T., Kondiah, P.P.D., and Choonara, Y.E. (2020). Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment. Cancers, 12. · DOI
  107. Borkowska, M., Siek, M., Kolygina, D.V., Sobolev, Y.I., Lach, S., Kumar, S., Cho, Y., Kandere-grzybowska, K., and Grzybowski, B.A. (2020). Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells. Nat. Nanotechnol. · DOI
  108. Jacob, 2020, Emerging role of nanosuspensions in drug delivery systems, Biomater. Res., 24, 1, 10.1186/s40824-020-0184-8 · DOI
  109. Yadollahi, 2015, Nanosuspension Technologies for Delivery of Poorly Soluble Drugs, J. Nanomater., 2015, 1, 10.1155/2015/216375 · DOI
  110. Wu, 2011, Physical and chemical stability of drug nanoparticles ☆, Adv. Drug Deliv. Rev., 63, 456, 10.1016/j.addr.2011.02.001 · DOI
  111. Patel, 2011, Nanosuspension: An approach to enhance solubility of drugs, J. Adv. Pharm. Technol. Res., 2, 81, 10.4103/2231-4040.82950 · DOI
  112. Li, J., Cai, C., Li, J., Li, J., Li, J., Sun, T., Wang, L., Wu, H., and Yu, G. (2018). Chitosan-Based Nanomaterials for Drug Delivery. Molecules, 23. · DOI
  113. Chenthamara, 2019, Therapeutic efficacy of nanoparticles and routes of administration, Biomater. Res., 23, 1, 10.1186/s40824-019-0166-x · DOI
  114. Wang, 2011, Recent advances of chitosan nanoparticles as drug carriers, Int. J. Nanomed., 6, 765
  115. Garg, 2019, Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting, Adv. Pharm. Bull, 7, 113
  116. Gaikwad, 2013, Polymers influencing transportability profile of drug, Saudi Pharm. J., 21, 327, 10.1016/j.jsps.2012.10.003 · DOI
  117. Solnier, J., Martin, L., and Bhakta, S. (2020). molecules Flavonoids as Novel Efflux Pump Inhibitors and Antimicrobials Against Both Environmental and Pathogenic Intracellular Mycobacterial Species. Molecules, 25. · DOI
  118. Muxika, 2017, Chitosan as a bioactive polymer: Processing, properties and applications, Int. J. Biol. Macromol., 105, 1358, 10.1016/j.ijbiomac.2017.07.087 · DOI
  119. Farasat, 2019, Effective suppression of tumour cells by oligoclonal HER2-targeted delivery of liposomal doxorubicin, J. Liposome Res., 29, 53, 10.1080/08982104.2018.1430829 · DOI
  120. Persi, E., Duran-Frigola, M., Damaghi, M., Roush, W.R., Aloy, P., Cleveland, J.L., Gillies, R.J., and Ruppin, E. (2018). Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat. Commun., 9. · DOI
  121. Nate, 2013, Polymeric conjugates for drug delivery, Chem. Mater., 24, 840
  122. Lamberti, 2014, Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity, World J. Clin Oncol., 5, 901, 10.5306/wjco.v5.i5.901 · DOI
  123. Gu, 2018, Applications of stimuli-responsive nanoscale drug delivery systems in translational research, Drug Discov. Today, 23, 1043, 10.1016/j.drudis.2017.11.009 · DOI
  124. Chen, 2017, Co-delivery of paclitaxel and anti-survivin siRNA via redox-sensitive oligopeptide liposomes for the synergistic treatment of breast cancer and metastasis, Int. J. Pharm., 529, 102, 10.1016/j.ijpharm.2017.06.071 · DOI
  125. Ghorbani, 2017, Redox and pH-responsive gold nanoparticles as a new platform for simultaneous triple anti-cancer drugs targeting, Int. J. Pharm., 520, 126, 10.1016/j.ijpharm.2017.02.008 · DOI
  126. Zhang, 2019, pH and redox dual-responsive nanoparticles based on disulfide-containing poly(beta-amino ester) for combining chemotherapy and COX-2 inhibitor to overcome drug resistance in breast cancer, J. Nanobiotechnol., 17, 109, 10.1186/s12951-019-0540-9 · DOI

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Metadata

Authors
Herdiana, Y., Wathoni, N., Shamsuddin, S., Joni, I. M., & Muchtaridi, M.
Venue
Polymers
Publisher
MDPI AG
Published
2021-05-24
Volume
13
Issue
11
Pages
1717
ISSN
2073-4360
DOI
10.3390/polym13111717
PMC
PMC8197416
Cited by
196
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • Academic Leadership Grant (ALG) (1427/UN6.3.1/LT/2020)
  • Riset Disertasi Doktor Unpad (RDDU) (2020)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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