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Cited by 25Hydrogels: synthesis, properties, applicationsAdvanced Drug Delivery SystemsGlioma Diagnosis and Treatment

Intracranial In Situ Thermosensitive Hydrogel Delivery of Temozolomide Accomplished by PLGA–PEG–PLGA Triblock Copolymer Blending for GBM Treatment

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Gu, Weinan, Fan, Ranran, Quan, Jingnan, Cheng, Yi, Wang, Shanshan, Zhang, Hui, Zheng, Aiping, Song, Shenghan·2022·Polymers
DOI 10.3390/polym14163368PMC PMC9413267
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Abstract

Glioblastoma (GBM) recurrence after surgical excision has grown to be a formidable obstacle to conquer. In this research, biodegradable thermosensitive triblock copolymer, poly(D, L–lactic acid–co–glycolic acid)–b–poly(ethylene glycol)–b–poly(D, L–lactic acid–co–glycolic acid (PLGA–PEG–PLGA) was utilized as the drug delivery system, loading with micronized temozolomide(micro-TMZ) to form an in situ drug–gel depot inside the resection cavity. The rheology studies revealed the viscoelastic profile of hydrogel under various conditions. To examine the molecular characteristics that affect gelation temperature, 1H–NMR, inverse gated decoupling 13C–NMR, and GPC were utilized. Cryo-SEM and XRD were intended to disclose the appearance of the hydrogel and the micro-TMZ existence state. We worked out how to blend polymers to modify the gelation point (Tgel) and fit the correlation between Tgel and other dependent variables using linear regression. To simulate hydrogel dissolution in cerebrospinal fluid, a membraneless dissolution approach was used. In vitro, micro-TMZ@PLGA–PEG–PLGA hydrogel exhibited Korsmeyer–Peppas and zero–order release kinetics in response to varying drug loading, and in vivo, it suppressed GBM recurrence at an astoundingly high rate. Micro-TMZ@PLGA–PEG–PLGA demonstrates a safer and more effective form of chemotherapy than intraperitoneal TMZ injection, resulting in a spectacular survival rate (40%, n = 10) that is much more than intraperitoneal TMZ injection (22%, n = 9). By proving the viability and efficacy of micro-TMZ@PLGA–PEG–PLGA hydrogel, our research established a novel chemotherapeutic strategy for treating GBM recurrence.

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  • PLGA can be formulated into injectable hydrogels, offering minimally invasive application and localized adhesion prevention, particularly in complex surgical sites.

    “Additionally, PLGA can be formulated into injectable hydrogels, which offer minimally invasive application and localized adhesion prevention, particularly in complex surgical sites [230].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [230]

    The Materials and Methods section (2.4) describes intracranial injection of a PLGA–PEG–PLGA hydrogel, supporting the injectable-hydrogel part of the claim. The paper studies local delivery for glioblastoma treatment, but the passages do not report adhesion prevention or establish a minimally invasive advantage in complex surgical sites. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Gu, W., Fan, R., Quan, J., Cheng, Y., Wang, S., Zhang, H., Zheng, A., & Song, S.
Affiliations
  • Xuzhou Medical College (CN)
  • State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Beijing 100850, China
  • Capital Medical University (CN)
Corresponding author
  • Zheng, Aiping
  • Song, Shenghan
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2022-08-18
Volume
14
Issue
16
Pages
3368
ISSN
2073-4360 (ISSN-L)
DOI
10.3390/polym14163368
PMC
PMC9413267
OpenAlex
W4293514197
Cited by
25
References
0
Citations by year
2026: 7 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 1
FWCI
1.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Polymers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Natural Science Foundation of China (81573357)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
Keywords
recurrent glioblastoma, temozolomide, thermosensitive hydrogel, PLGA-PEG-PLGA triblock copolymer, local drug delivery, polymer blending, drug release kinetics, resection cavity, biodegradable polymers, survival rate

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