Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective
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Abstract
By providing useful tools to study host–pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of proteogenomics approaches to study bacterial pathogenesis. In addition, we review different omics strategies (i.e., transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host.
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Cites
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Flagged first, then by citations
- Authors
- Fels, U., Gevaert, K., & Van Damme, P.
- Affiliations
- Ghent University (BE)
- VIB-UGent Center for Medical Biotechnology, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium
- Venue
- Proteomes
- Publisher
- MDPI AG
- Published
- 2017-10-11
- Volume
- 5
- Issue
- 4
- Pages
- 26
- ISSN
- 2227-7382 (ISSN-L)
- PMC
- PMC5748561
- OpenAlex
- W2763353276
- Cited by
- 17
- References
- 7
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 5 · 2018: 4
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Proteomes (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Université Paris-Est Créteil Val-de-Marne
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- proteogenomics, host-pathogen interaction, bacterial pathogenesis, pathogenic bacteria, transcriptomics, proteomics, secretomics, multi-omics integration
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