EGFET-Based Sensors for Bioanalytical Applications: A Review
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Abstract
Since the 1970s, a great deal of attention has been paid to the development of semiconductor-based biosensors because of the numerous advantages they offer, including high sensitivity, faster response time, miniaturization, and low-cost manufacturing for quick biospecific analysis with reusable features. Commercial biosensors have become highly desirable in the fields of medicine, food, and environmental monitoring as well as military applications, whereas increasing concerns about food safety and health issues have resulted in the introduction of novel legislative standards for these sensors. Numerous devices have been developed for monitoring biological processes such as nucleic acid hybridization, protein–protein interaction, antigen–antibody bonds, and substrate–enzyme reactions, just to name a few. Since the 1980s, scientific interest moved to the development of semiconductor-based devices, which also include integrated front-end electronics, such as the extended-gate field-effect transistor (EGFET) biosensor, one of the first miniaturized chemical sensors. This work is intended to be a review of the state of the art focused on the development of biosensors and chemosensors based on extended-gate field-effect transistor within the field of bioanalytical applications, which will highlight the most recent research reported in the literature. Moreover, a comparison among the diverse EGFET devices will be presented, giving particular attention to the materials and technologies.
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Electrochemical glucose sensors can be divided into potentiometric, amperometric, or conductometric.
“Electrochemical glucose sensors can be divided into potentiometric (employed to detect variations of surface charge onto a counter electrode), amperometric (charge flow between the counter electrode and the bio-system), or conductometric (variations in ionic conductance between electrodes) 74,75.”
From Glucose biosensors in clinical practice: principles, limits and perspectives of currently used devices (2022) · cites this paper as [75]
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References 216 · Cited by 197
Research works printed but not linked: 20
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- Authors
- Pullano, S. A., Critello, C. D., Mahbub, I., Tasneem, N. T., Shamsir, S., Islam, S. K., Greco, M., & Fiorillo, A. S.
- Affiliations
- Magna Graecia University (IT)
- University of North Texas (US)
- University of Missouri (US)
- Corresponding author
- Pullano, Salvatore Andrea
- ORCID
- Venue
- Sensors
- Publisher
- MDPI AG
- Published
- 2018-11-20
- Volume
- 18
- Issue
- 11
- Pages
- 4042
- ISSN
- 1424-8220 (ISSN-L)
- PMC
- PMC6263563
- OpenAlex
- W2900514596
- Cited by
- 197
- References
- 216
- Citations by year
- 2026: 26 · 2025: 20 · 2024: 38 · 2023: 19 · 2022: 34 · 2021: 27 · 2020: 17 · 2019: 15 · 2018: 1
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Sensors (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- University of North Texas Digital Library (University of North Texas) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- extended-gate field-effect transistor, semiconductor biosensors, chemical sensors, bioanalytical applications, nucleic acid hybridization, protein-protein interaction, antigen-antibody reaction
- MeSH terms
- Calcium, DNA, Glucose, Humans, Miniaturization, Transistors, Electronic, Urea, Biosensing Techniques, Electrochemical Techniques
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