Chaperoning the Mononegavirales: Current Knowledge and Future Directions
Open accessPublished version of a preprint
Abstract
The order Mononegavirales harbors numerous viruses of significant relevance to human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses, and antiviral therapies remain limited. Being obligate cellular parasites, viruses must utilize the cellular machinery for their replication and spread. Therefore, targeting cellular pathways used by viruses can provide novel therapeutic approaches. One of the key challenges confronted by both hosts and viruses alike is the successful folding and maturation of proteins. In cells, this task is faced by cellular molecular chaperones, a group of conserved and abundant proteins that oversee protein folding and help maintain protein homeostasis. In this review, we summarize the current knowledge of how the Mononegavirales interact with cellular chaperones, highlight key gaps in our knowledge, and discuss the potential of chaperone inhibitors as antivirals.
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- Authors
- Latorre, V., Mattenberger, F., & Geller, R.
- Affiliations
- Institute for Integrative Systems Biology (I2SysBio), Universitat de Valencia-CSIC, 46980 Valencia, Spain
- Consejo Superior de Investigaciones Científicas (ES)
- Corresponding author
- Geller, Ron
- Venue
- Viruses
- Publisher
- MDPI AG
- Published
- 2018-12-08
- Volume
- 10
- Issue
- 12
- Pages
- 699
- ISSN
- 1999-4915 (ISSN-L)
- PMC
- PMC6315898
- OpenAlex
- W2903821562
- Cited by
- 14
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 3
- FWCI
- 0.12
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Viruses (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Conselleria d'Educació, Investigació, Cultura i Esport (SEJI/2017/006)
- European Society of Clinical Microbiology and Infectious Diseases (Research Grant 2017)
- Ministerio de Ciencia, Innovación y Universidades (BES-2016-076677)
- Ministerio de Economía y Competitividad (RYC-2015-17517)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
- Keywords
- Mononegavirales, chaperone inhibitors, antiviral therapy, protein folding, proteostasis, host-virus interaction, emerging viral diseases, vaccine development
- MeSH terms
- Antiviral Agents, Humans, Measles virus, Respiratory Syncytial Viruses, Virus Replication, Protein Folding, Mononegavirales, Molecular Chaperones, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Host-Pathogen Interactions
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