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Willingness to Receive Maternal RSV Vaccination Among Pregnant Women and Those Planning Pregnancy in Southern China: A Cross-Sectional Study and Predictive Nomogram

Meng, Xiang, Li, Sijie, Li, Meiyan, Guo, Cheng, Wang, Ping, Chen, Xuejuan, Zhang, Dingmei, Zhong, Yonghui·2026·Vaccines
DOI 10.3390/vaccines14020160
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Abstract

Background/Objectives: Maternal immunization against respiratory syncytial virus (RSV) is an emerging strategy to protect infants during early life when they are most vulnerable to severe RSV infection. However, little is known about the willingness to receive maternal RSV vaccination in China, where the vaccine has not yet been officially approved for marketing. This study aimed to assess the willingness to receive maternal RSV vaccination among women who are currently pregnant and those planning pregnancy in Guangzhou, and to identify the key determinants influencing vaccination willingness. Methods: A cross-sectional survey was conducted in April 2025 among 406 women at Guangzhou Women and Children’s Medical Center, China. Participants completed a self-administered questionnaire covering predisposing factors, enabling resources, health behaviors and awareness, and need factors. Logistic regression analyses were used to identify factors associated with vaccine willingness. A nomogram prediction model was constructed based on significant predictors. Results: Overall, 67.2% (n = 273) of participants reported willingness to receive maternal RSV vaccination. Younger maternal age, higher levels of social support, moderate or high perceived RSV risk, a history of HPV vaccination, and having medical insurance were independently associated with higher willingness to vaccinate. A predictive nomogram incorporating these factors demonstrated good discrimination (AUC = 0.753) and calibration. Age-stratified analysis revealed differing concerns across age groups, with vaccine safety and neonatal protection being the most cited factors influencing decision-making. Conclusions: This study provides the first evidence on maternal RSV vaccination willingness in southern China and highlights several psychosocial and demographic factors influencing vaccine intentions. The nomogram offers a practical tool to estimate individual willingness and guide targeted communication. These findings have implications for future maternal RSV vaccine application strategies in China.

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Research works printed but not linked: 44

  1. Langedijk, 2023, Respiratory syncytial virus infection and novel interventions, Nat. Rev. Microbiol., 21, 734, 10.1038/s41579-023-00919-w · DOI
  2. Simoes, 1999, Respiratory syncytial virus infection, Lancet, 354, 847, 10.1016/S0140-6736(99)80040-3 · DOI
  3. Sirimi, 2016, Respiratory syncytial virus activity and climate parameters during a 12-year period, J. Med. Virol., 88, 931, 10.1002/jmv.24430 · DOI
  4. Li, 2021, Etiological and epidemiological features of acute respiratory infections in China, Nat. Commun., 12, 5026, 10.1038/s41467-021-25120-6 · DOI
  5. Du, 2023, Global burden and trends of respiratory syncytial virus infection across different age groups from 1990 to 2019: A systematic analysis of the Global Burden of Disease 2019 Study, Int. J. Infect. Dis., 135, 70, 10.1016/j.ijid.2023.08.008 · DOI
  6. Li, 2022, Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: A systematic analysis, Lancet, 399, 2047, 10.1016/S0140-6736(22)00478-0 · DOI
  7. Anderson, 2013, Respiratory syncytial virus vaccine development, Semin. Immunol., 25, 160, 10.1016/j.smim.2013.04.011 · DOI
  8. Melero, 2013, Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity, Curr. Top. Microbiol. Immunol., 372, 59
  9. Nam, 2019, Respiratory syncytial virus infection in adults, BMJ, 366, l5021, 10.1136/bmj.l5021 · DOI
  10. Ngwuta, 2015, Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera, Sci. Transl. Med., 7, 309ra162, 10.1126/scitranslmed.aac4241 · DOI
  11. Coindy, 2024, Antibody-mediated protection against respiratory syncytial virus in children, Eur. Respir. Rev., 33, 240106, 10.1183/16000617.0106-2024 · DOI
  12. Huang, J., Diaz, D., and Mousa, J.J. (2019). Antibody Epitopes of Pneumovirus Fusion Proteins. Front. Immunol., 10. · DOI
  13. Koivisto, 2022, Respiratory Syncytial Virus (RSV)–Specific Antibodies in Pregnant Women and Subsequent Risk of RSV Hospitalization in Young Infants, J. Infect. Dis., 225, 1189, 10.1093/infdis/jiab315 · DOI
  14. Capella, 2017, Prefusion F, Postfusion F, G Antibodies, and Disease Severity in Infants and Young Children with Acute Respiratory Syncytial Virus Infection, J. Infect. Dis., 216, 1398, 10.1093/infdis/jix489 · DOI
  15. Duan, 2024, Landscape of respiratory syncytial virus, Chin. Med. J., 137, 2953, 10.1097/CM9.0000000000003354 · DOI
  16. Kampmann, 2023, Bivalent Prefusion F Vaccine in Pregnancy to Prevent RSV Illness in Infants, N. Engl. J. Med., 388, 1451, 10.1056/NEJMoa2216480 · DOI · Paper page
  17. Shoukat, 2023, Cost-effectiveness analysis of nirsevimab and maternal RSVpreF vaccine strategies for prevention of Respiratory Syncytial Virus disease among infants in Canada: A simulation study, Lancet Reg. Health–Am., 28, 100629
  18. Wang, 2025, Cost-effectiveness analysis of nirsevimab for prevention of respiratory syncytial virus disease among infants in Shanghai, China: A modeling study, Hum. Vaccines Immunother., 21, 2506288, 10.1080/21645515.2025.2506288 · DOI
  19. Saso, 2016, Vaccination against respiratory syncytial virus in pregnancy: A suitable tool to combat global infant morbidity and mortality?, Lancet Infect. Dis., 16, e153, 10.1016/S1473-3099(16)00119-5 · DOI
  20. Averin, 2024, Cost-Effectiveness of Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Vaccine During Pregnancy for Prevention of Respiratory Syncytial Virus Among Infants in Argentina, Infect. Dis. Ther., 13, 2363, 10.1007/s40121-024-01055-5 · DOI
  21. Zheng, 2022, Predicted effectiveness of vaccines and extended half-life monoclonal antibodies against RSV hospitalizations in children, npj Vaccines, 7, 127, 10.1038/s41541-022-00550-5 · DOI
  22. Shaw, 2013, The path to an RSV vaccine, Curr. Opin. Virol., 3, 332, 10.1016/j.coviro.2013.05.003 · DOI
  23. Jasseh, 2025, Feasibility and Acceptability of Respiratory Syncytial Virus Vaccination in Mothers for Infant Protection at Edward Francis Small Teaching Hospital, the Gambia, J. Epidemiol. Glob. Health, 15, 118, 10.1007/s44197-025-00467-x · DOI
  24. McClymont, 2025, Acceptance and preference between respiratory syncytial virus vaccination during pregnancy and infant monoclonal antibody among pregnant and postpartum persons in Canada, Vaccine, 50, 126818, 10.1016/j.vaccine.2025.126818 · DOI · Paper page
  25. Sallam, 2025, Attitude to RSV Vaccination Among a Cohort of Pregnant Women in Jordan: A Cross-Sectional Survey Study, Health Sci. Rep., 8, e70319, 10.1002/hsr2.70319 · DOI · Paper page
  26. Lubrano, C., Locati, F., Casaccia, F., Trespidi, L., Cucchi, R., Parisi, F., Ossola, M.W., and Cetin, I. (Eur. J. Public Health, 2025). Italian survey on maternal acceptance and views on RSV vaccination during pregnancy, Eur. J. Public Health, published online ahead of print. · DOI
  27. Miraglia Del Giudice, G., Sansone, V., Airoma, F., Angelillo, S., Licata, F., and Di Giuseppe, G. (2023). Respiratory Syncytial Virus: Willingness towards a Future Vaccine among Pregnant Women in Italy. Vaccines, 11. · DOI · Paper page
  28. Saper, 2024, RSV Vaccination Intention Among People Who Are or Plan to Become Pregnant, Pediatrics, 153, e2023065140, 10.1542/peds.2023-065140 · DOI · Paper page
  29. Cubizolles, 2023, Evaluation of intentions to get vaccinated against influenza, COVID 19, pertussis and to get a future vaccine against respiratory syncytial virus in pregnant women, Vaccine, 41, 7342, 10.1016/j.vaccine.2023.10.067 · DOI
  30. Babitsch, 2012, Re-revisiting Andersen’s Behavioral Model of Health Services Use: A systematic review of studies from 1998–2011, GMS Psycho Soc. Med., 9, Doc11
  31. Lu, 2024, Knowledge, attitudes, and perceptions of influenza vaccine among pregnant women in Minhang District, Shanghai, Hum. Vaccines Immunother., 20, 2368944, 10.1080/21645515.2024.2368944 · DOI
  32. Preis, 2023, Factors related to COVID-19 vaccination intention and uptake among childbearing women, Health Psychol., 42, 567, 10.1037/hea0001221 · DOI
  33. Tavakol, 2011, Making sense of Cronbach’s alpha, Int. J. Med. Educ., 2, 53, 10.5116/ijme.4dfb.8dfd · DOI · Paper page
  34. Bursac, 2008, Purposeful selection of variables in logistic regression, Source Code Biol. Med., 3, 17, 10.1186/1751-0473-3-17 · DOI · Paper page
  35. Collins, 2014, Increased awareness and health care provider endorsement is required to encourage pregnant women to be vaccinated, Hum. Vaccines Immunother., 10, 2922, 10.4161/21645515.2014.971606 · DOI
  36. Widdershoven, V., Reijs, R.P., Eskes, A., Verhaegh-Haasnoot, A., and Hoebe, C.J.P.A. (2023). Acceptance of vaccination against pertussis, COVID-19 and influenza during pregnancy: A cross-sectional study. BMC Pregnancy Childbirth, 23. · DOI
  37. Jiang, 2024, Factors associated with pregnant women’s willingness to receive maternal pertussis vaccination in Guizhou Province, China: An exploratory cross-sectional study, Hum. Vaccines Immunother., 20, 2331870, 10.1080/21645515.2024.2331870 · DOI
  38. Yakut, 2020, Knowledge and acceptance of influenza and pertussis vaccinations among pregnant women of low socioeconomic status in Turkey, Hum. Vaccines Immunother., 16, 1101, 10.1080/21645515.2019.1689082 · DOI
  39. Shamshirsaz, 2022, Intention to Receive COVID-19 Vaccine during Pregnancy: A Systematic Review and Meta-analysis, Am. J. Perinatol., 39, 492, 10.1055/a-1674-6120 · DOI
  40. Razzaghi, 2020, Influenza and Tdap Vaccination Coverage Among Pregnant Women—United States, April 2020, Mmwr-Morbidity Mortal. Wkly. Rep., 69, 1391, 10.15585/mmwr.mm6939a2 · DOI
  41. An, S., and Sun, S. (2023). Serial multiple mediation of perceived professional healthcare support and social structural factors in the relationship between care-seeking behavior and perinatal mental health in Chinese mothers. BMC Public Health, 23. · DOI
  42. Yang, R., Penders, B., and Horstman, K. (2020). Vaccine Hesitancy in China: A Qualitative Study of Stakeholders’ Perspectives. Vaccines, 8. · DOI
  43. Zhang, L., Yang, J., Cao, Y., and Kang, W. (2023). Sociocultural–psychological predictors influencing parents’ decision-making regarding HPV vaccination for their adolescent daughters in mainland China: An extended TPB model. Front. Public Health, 10. · DOI
  44. Sacre, A., Bambra, C., Wildman, J.M., Thomson, K., Bennett, N., Sowden, S., and Todd, A. (2023). Socioeconomic inequalities in vaccine uptake: A global umbrella review. PLoS ONE, 18. · DOI

Metadata

Authors
Meng, X., Li, S., Li, M., Guo, C., Wang, P., Chen, X., Zhang, D., & Zhong, Y.
Venue
Vaccines
Publisher
MDPI AG
Published
2026-02-08
Volume
14
Issue
2
Pages
160
ISSN
2076-393X
DOI
10.3390/vaccines14020160
Cited by
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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CoChat. (2026). Citation check: Willingness to Receive Maternal RSV Vaccination Among Pregnant Women and Those Planning Pregnancy in Southern China: A Cross-Sectional Study and Predictive Nomogram. https://app.cochat.ai/papers/10.3390/vaccines14020160
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Meng, X., Li, S., Li, M., Guo, C., Wang, P., Chen, X., Zhang, D., & Zhong, Y. (2026). Willingness to Receive Maternal RSV Vaccination Among Pregnant Women and Those Planning Pregnancy in Southern China: A Cross-Sectional Study and Predictive Nomogram. Vaccines. https://doi.org/10.3390/vaccines14020160