Immune Responses Induced by mRNA Vaccination in Mice, Monkeys and Humans
Open accessAbstract
In this concise review, we summarize the concepts behind mRNA vaccination. We discuss the innate and adaptive immune response generated by mRNA vaccines in different animal models and in humans. We give examples of viral infections where mRNA vaccines have shown to induce potent responses and we discuss in more detail the recent SARS-CoV-2 mRNA vaccine trials in humans.
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More robust germinal centre responses are consistent with antigen dissemination to multiple lymph nodes and the self-adjuvating characteristics of the mRNA-lipid nanoparticle vaccine platform compared to nonadjuvanted inactivated vaccines used for seasonal influenza virus vaccination.
“More robust germinal centre responses are consistent with antigen dissemination to multiple lymph nodes and the self-adjuvating characteristics of the mRNA–lipid nanoparticle vaccine platform compared to nonadjuvanted inactivated vaccines used for seasonal influenza virus vaccination7,20,21.”
From SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses (2021) · cites this paper as [7]
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References 86 · Cited by 153
- Authors
- Cagigi, A., & Loré, K.
- Affiliations
- Karolinska University Hospital (SE)
- Corresponding author
- Loré, Karin
- Venue
- Vaccines
- Publisher
- MDPI AG
- Published
- 2021-01-18
- Volume
- 9
- Issue
- 1
- Pages
- 61
- ISSN
- 2076-393X (ISSN-L)
- PMC
- PMC7831080
- OpenAlex
- W3122097151
- Cited by
- 153
- References
- 86
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 20 · 2023: 34 · 2022: 37 · 2021: 35
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Vaccines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Swedish Research Council (Vetenskapsrådet) (2020-05829, 2019-01036)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- mRNA vaccines, innate immune response, adaptive immune response, SARS-CoV-2, COVID-19 vaccines, viral infection, animal models, vaccine clinical trials, immunogenicity
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