Detailed Dissection and Critical Evaluation of the Pfizer/BioNTech and Moderna mRNA Vaccines

Xia, Xuhua·2021·Vaccines

Cited by (203)

Items 101–200 of 203

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  4. mRNA vaccines encoding membrane-anchored RBDs of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting
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  5. SARS-CoV-2 mRNA vaccine is re-adenylated in vivo , enhancing antigen production and immune response
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  7. Trans amplifying mRNA vaccine expressing consensus spike elicits broad neutralization of SARS CoV 2 variants
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  8. Selection of UTRs in mRNA-Based Gene Therapy and Vaccines
    Volkhin, Ilya A., Paremskaia, Anastasia Iu., Dashian, Maria A., Smeshnova, Darya S., Pavlov, Roman E., Mityaeva, Olga N., Volchkov, Pavel Yu., Deviatkin, Andrei A. · 2025 · Biochemistry (Moscow)
  9. Future prospects in mRNA vaccine development
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  10. Optimizing Nucleic Acid Delivery Systems through Barcode Technology
    Soan Park, Mibang Kim, Jeong Wook Lee · 2024 · ACS Synthetic Biology
  11. SARS‐CoV‐2 Evolution: Immune Dynamics, Omicron Specificity, and Predictive Modeling in Vaccinated Populations
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  12. SARS-CoV2 and Anti-COVID-19 mRNA Vaccines: Is There a Plausible Mechanistic Link with Cancer?
    Ciro Isidoro · 2025 · Cancers
  13. Engineering Anti-Tumor Immunity: An Immunological Framework for mRNA Cancer Vaccines
    Olivia Roy, Karen S. Anderson · 2025 · Vaccines
  14. Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods
    Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen · 2026 · MedComm
  15. Personalized immunization to optimize vaccine immunogenicity: exploring the multidimensional effects of host intrinsic factors, external intervention strategies, and the external environment
    Keda Chen, Siyi Gu, Jiaxuan Li, Yutong Xu, Zhiyi Wang, Yanjun Zhang, Jianhua Li · 2025 · Frontiers in Immunology
  16. Recent advances in engineering approaches for delivery of mRNA-based therapeutics
    Ken Ninez Nurpramesti Prinindya, Ghulam Md Ashraf, Shihab Uddin, Elsadig Mahdi, Anwarul Hasan · 2025 · Biomaterials Advances
  17. Overview of drugs approved by the FDA in 2022
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  18. Characterization of poly(A) and poly(T) tail lengths in plasmid DNA by liquid chromatography high-resolution mass spectrometry
    Nour Al Turihi, Delphine Allouche, Maëlle Quéré, Mathieu Scuiller, Isabelle Legastelois · 2024 · Analytical and Bioanalytical Chemistry
  19. COVID-19 mRNA vaccines as hypothetical epigenetic players: Results from an in silico analysis, considerations and perspectives
    Rossella Talotta · 2023 · Vaccine
  20. Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice
    Dominik Pflumm, Alina Seidel, Fabrice A. C. Klein, Rüdiger M. Groß, Lea Krutzke, Stefan Kochanek, Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck · 2023 · Frontiers in Immunology
  21. Comparative Analysis of Lipid Nanoparticles in Pfizer-BioNTech and Moderna COVID-19 Vaccines: Insights from Molecular Dynamics Simulations
    Malay Ranjan Biswal, Sudip Kumar Roy, Jayant Kumar Singh · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Immunogenicity Evaluation of Combination Respiratory Syncytial Virus and Varicella–Zoster Virus mRNA Vaccines in C57BL/6J Mice
    Ning Luan, Luxia Huang, Jingping Hu, Haihao Zhang, Dandan Gao, Zhentao Lei, Xiaolong Zhang, Han Cao, Cunbao Liu · 2025 · Vaccines
  23. A viral codon usage strategy enhances antigen production and protection in SFTSV mRNA vaccination
    In–Ho Cha, Yumiko Yamada, Do-Kyun Kim, Soowon Kang, Wan-Shan Yang, Woo-Jin Shin, Anna Ryder, Morgan Lewis, Chloe Chung, Nam-Hyuk Cho et al. · 2025 · npj Vaccines
  24. Evolution and Functional Implications of Codon Usage Bias in Eukaryotes
    Ujwal Dahal, Rupendra Shakya, Bhumandeep Kour, Binju Khanal, Bhupinder Singh · 2026 · Journal of Molecular Evolution
  25. An Immunoreceptor-Targeting Strategy with Minimalistic C3b Peptide Fusion Enhances SARS-CoV-2 RBD mRNA Vaccine Immunogenicity
    Chun-Ta Chiu, Hsiao‐Han Tsai, Jing-Yuan Chen, Che‐Ming Jack Hu, Hui‐Wen Chen · 2024 · International Journal of Nanomedicine
  26. Research progress in mRNA drug modification and delivery systems
    Zhengjie Zhou, Xin Li · 2023 · Journal of Zhejiang University (Medical Sciences)
  27. The role of vaccination route with an adenovirus-vectored vaccine in protection, viral control, and transmission in the SARS-CoV-2/K18-hACE2 mouse infection model
    Alexandria M. Dickson, E. Geerling, E. T. Stone, Mariah Hassert, Tara L. Steffen, Taneesh Makkena, Madeleine Smither, Katherine E. Schwetye, Jianfeng Zhang, B. Georges et al. · 2023 · Frontiers in Immunology
  28. A New Approach to In Vivo Transformation of Killer T Cells
    Noe Rodriguez, Christian Hofmann, Otto O. Yang, William M. Gelbart · 2025 · Journal of Molecular Biology
  29. Research progress on mRNA drug delivery strategies in the nervous system
    Bo Yang, Anqi Liu, Xiaojing Li, Zhigang Miao · 2025 · Nanomedicine
  30. Potential of MRNA vaccines for mpox prevention: current evidence and future directions
    Toufik Abdul‐Rahman, Evelyn Faith Ogungbemi, Oyinbolaji Akinwande Ajetunmobi, Hala Ibrahim Thaalibi, Chinelo Geraldine Ikele, Gargi Gautam, Omotayo Faith Olanrewaju, Poulami Roy, Alhazan Amir Adebayo, Muslimat Abolore Mojeed et al. · 2025 · Annals of Medicine and Surgery
  31. Roadmap to the Development of mRNA Therapeutics: From Molecule Design and Delivery Strategies to Manufacturing, Quality Control, and Regulatory Considerations
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  32. A Design of mRNA-Based COVID-19 Vaccine Through Fuzzy Neural Network
    Farnaz Sabahi · 2023 · IEEE Transactions on Computational Biology and Bioinformatics
  33. Beyond the injection site: identifying the cellular targets of mRNA vaccines
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  34. An Elite Archive-Assisted Multi-Objective Evolutionary Algorithm for mRNA Design
    Wenjing Hong, Cheng Chen, Zexuan Zhu, Ke Tang · 2024 · IEEE Congress on Evolutionary Computation (CEC)
  35. AntigenBoost: enhanced mRNA-based antigen expression through rational amino acid substitution
    Gao Y, Siran Zhu, Hui‐Chun Li, Xueting Hao, Wen Chen, Deng Pan, Zhikang Qian · 2024 · Briefings in Bioinformatics
  36. Bridging One Health: Computational design of a multi-epitope messenger RNA vaccine for cross-species immunization against Nipah virus
    Edward C. Banico, Ella Mae Joy S. Sira, Lauren Emily Fajardo, Fredmoore Legaspi Orosco · 2024 · International Journal of One Health
  37. How Trustworthy Are the Genomic Sequences of SARS-CoV-2 in GenBank?
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  38. Application of the iPLUS non-coding sequence in improving biopharmaceuticals production
    Inês Reis-Claro, Maria Inês Silva, Ana Moutinho, Beatriz C. Garcia, Isabel Pereira‐Castro, Alexandra Moreira · 2024 · Frontiers in Bioengineering and Biotechnology
  39. RNA‐Guided RNA Pseudouridylation and 2’‐O‐Methylation
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  40. mRNA-Vaccine Platform: Features of Obtaining and Delivery of mRNA
    Victoria R. Litvinova, А. П. Рудометов, Л. И. Карпенко, A. A. Ilyichev · 2023 · Биоорганическая химия
  41. COVID-19 vaccination atlas using an integrative systems vaccinology approach
    Wasim Aluísio Prates-Syed, Dennyson Leandro M. Fonseca, Shahab Zaki Pour, Aline Aparecida de Lima Lira, Nelson Côrtes, Jaqueline Dinis Queiroz Silva, Evelyn Carvalho, Igor Salerno Filgueiras, Tania Geraldine Churasacari Vinces, Lena F. Schimke et al. · 2025 · npj Vaccines
  42. mRNA-based immunotherapy platform targeting endometrial cancer
    M. Freyberg, Martha Dierks, Norbert Naß, Christopher George, Maria Geffken, Atanas Ignatov, Thomas Kalinski, Zoya Ignatova · 2025 · Journal of Translational Medicine
  43. Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline
    Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song · 2025 · Advanced Science
  44. Effect of ionizable lipid head and tail group modification on mRNA delivery efficiency
    Soan Park, Kanghun Lee, Hyun-Jung An, Enhui Lin, Sugyeom Kim, Hyeongseok Kim, Siheon Jeong, Snehagni Roy, Yeon Woo Kang, Jaehyuk Yang et al. · 2026 · Journal of Drug Delivery Science and Technology
  45. Global landscape of mRNA vaccine clinical trials: a systematic analysis of ClinicalTrials.gov data
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  46. Evolution of Translational Machinery in Fast- and Slow-Growing Bacteria
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  47. Structurally-optimised HPV16 E7/E6 mRNA–LPP mediates dose-sparing efficacy via tumour microenvironment reprogramming
    Shucai Sun, Yao Deng, Jiao Ren, Han Xiaotian, Jialuo Bing, Tangqi Wang, Zhanyihao Hao, Houwen Tian, Liang Zhang, Wenjie Tan · 2026 · Molecular Biomedicine
  48. Stoichiometry-induced differential selection on codon optimization among ribosomal protein genes in bacterial species
    Xuhua Xia · 2026 · Molecular Biology and Evolution
  49. CJ-1: an optimized mRNA platform with enhanced protein expression and minimal immunogenicity for therapeutic applications
    Seyoung Kim, Min Ju Jo, Min Seon Jeong, Minki Ha, Youngwook Ham, Jiye Hong, Daeyong Kim, Kyuha Yum, Jaewook Yeon, Sang‐Bae Han et al. · 2026 · Gene Therapy
  50. Recent progress in the rational design of mRNA vaccines
    Zijia Guo, Jiayan Fu, Luna Ran, Nengcheng Bao, Yadong Wang, Haiyang Dong, Xiaofeng Yang, Yongfeng Jin · 2026 · Molecular Therapy
  51. The MSH3 Gene From A Neuropsychiatrist’s Perspective
    Adonis Sfera, Dan O. Sfera, Sarvin Sasannia, Sabine Hazan · 2022 · Advances In Clinical And Medical Research
  52. Full comprehensive ion-pair-mediated anion exchange chromatography × ion-pair reversed-phase liquid chromatography fingerprinting of digested messenger ribonucleic acid drug substances
    Niklas Carstensen, Ryan Karongo, Anne Mengel, Michael Lämmerhofer · 2025 · Journal of Chromatography Open
  53. COVID-19 and Blood Clots: Is it only The Virus to be Blamed? What are new Updates? A Systematic Review
    Majid Mohammed Mahmood · 2022 · Journal of Cardiology and Cardiovascular Research
  54. Mechanisms that could increase cancer vulnerability in COVID-19 mRNA vaccine recipients
    Paz Azakarian · 2021
  55. Distinct evolution of infection-enhancing and neutralizing epitopes in the spike protein of SARS-CoV-2 variants (from alpha to omicron) : a structural and molecular epidemiology study
    Patrick GUERIN, Nouara Yahi, Fodil Azzaz, Henri Chahinian, Jean‐Marc Sabatier, Jacques Fantini · 2021 · Research Square
  56. Vaccination of elite athletes against SARS-CoV-2 and broader implications for public health policy
    James Sheehan · 2022
  57. COVID-19 vaccination atlas: an integrative systems vaccinology approach
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  58. Strategic Deactivation of mRNA COVID-19 Vaccines: New Applications for RIBOTACs and siRNA Therapy
    Nicolas Hulscher, Peter Andrew McCullough, Diane E. Marotta · 2024
  59. Modified or Unmodified mRNA Vaccines? – The Biochemistry of Pseudouridine and mRNA Pseudouridylation
    Pedro Morais, Yi‐Tao Yu · 2024 · Wiley eBooks
  60. CodonRL: Multi-Objective Codon Sequence Optimization Using Demonstration-Guided Reinforcement Learning
    Shiyi Du, Gün Kaynar, Jiayi Li, Zhaoyi You, Shijie Tang, Carl Kingsford · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  61. From Genetics to Epigenetics: Top 4 Aspects for Improved SARS-CoV-2 Vaccine Designs as Paradigmatic Examples
    Darja Kanduc · 2021 · Global Medical Genetics
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  63. Recording Silence – Accurate Annotation of the Genetic Sequence Is Required to Better Understand How Synonymous Coding Affects Protein Structure and Disease
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  64. Navigating Uncharted Waters: Could Certain COVID-19 Vaccines Promote Malignancy?
    Raquel Valdes Angues, Yolanda Perea Bustos · 2022
  65. Messenger RNA for Prophylaxis
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  66. Messenger RNA Nanovaccine in Cancer Immunotherapy
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  67. mRNA Covid-19 Pharmaceuticals and the Spike Antigen
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  68. Differences in BNT126b2 and ChAdOx1 Homologous Vaccination Antibody Response among Teachers in Poznan, Poland
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  69. Strukturierte RNAs in Viren
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  70. Design and Generation of MRNAS Encoding Conserved Regions of SARS-Cov-2 ORf1Ab for T Cell-Mediated Immune Activation
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  71. The Matryoshka code of COVID-19 mRNA vaccines: overlapping viral sequences?
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  72. A Global Network Analysis of COVID-19 Vaccine Distribution to Predict Breakthrough Cases Among the Vaccinated Population
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  73. Universal protection against SARS-CoV-2 viruses by multivalent mRNA vaccine in mice
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  74. Circulating Synthetic SARS-CoV-2 Spike Proteins Possibly Contribute to a Transient ACE2 Dysfunction Leading to Rare Cases of Myocarditis after COVID-19 mRNA Vaccination
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  77. Conclusions
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  91. Fundamentals of Translation
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  93. Codon optimization depletes stop codons in alternative reading frames of protein-coding nucleic acid therapeutics
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