Cancer Hacks Neurodegeneration: Cystatin-C as a Bridge for Microglial Amyloid Clearance via TREM2
Open accessAbstract
Historically, epidemiological studies have consistently highlighted an inverse correlation between cancer and Alzheimer’s disease, yet the molecular link between these 2 distinct pathologies remained elusive. In a recent breakthrough published in Cell , Li et al. provide a compelling answer by revealing that peripheral tumors secrete cystatin-C, which binds to preexisting amyloid oligomers and activates triggering receptor expressed on myeloid cells 2 (TREM2) in microglia, leading to the clearance of preexisting amyloid plaques in Alzheimer’s disease mice.
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Ewers, M., Biechele, G., Suárez‐Calvet, M., Sacher, C., Blume, T., Morenas‐Rodriguez, E., Deming, Y., Piccio, L., Cruchaga, C., Kleinberger, G., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012308 · Cited by 133 · see citing works
Huang, Q., Jiang, C., Xia, X., Wang, Y., Yan, C., Wang, X., Lei, T., Yang, X., Yang, W., Cheng, G., et al. (2023) · Research · doi:10.34133/research.0180 · Cited by 78 · cited 1× · see citing works
“Alternative routes, such as receptor-mediated delivery via chaperone peptides, warrant future explorations [ 20 ].”
Kleeman, S. O., Thakir, T. M., Demestichas, B., Mourikis, N., Loiero, D., Ferrer, M., Bankier, S., Riazat-Kesh, Y. J. R. A., Lee, H., Chantzichristos, D., et al. (2023) · Cell Genomics · doi:10.1016/j.xgen.2023.100347 · Cited by 37 · see citing works
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- Authors
- Zhang, Y., Li, C., & Li, C.
- Affiliations
- Chinese University of Hong Kong (HK)
- Department of Biomedical Engineering, Division of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.
- Corresponding author
- Li, Conglei
- Venue
- Research
- Published
- 2026-01-01
- Volume
- 9
- Pages
- 1456-1456
- ISSN
- 2639-5274 (ISSN-L)
- PMC
- PMC13662275
- OpenAlex
- W7214984332
- Cited by
- 0
- References
- 3
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Shenzhen Peacock Team (KQTD20240729102029016)
- Shenzhen Science and Technology Program (JCYJ20220530143417039)
- Shenzhen Medical Research Fund (B2402012)
- National Science Fund of China (82572095)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- cystatin C, microglia, amyloid clearance, TREM2, neurodegeneration, cancer, Alzheimer's disease, amyloid-beta
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