The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Topical Human Mesenchymal Stem Cell-Derived Exosomes for Acceleration of Wound Healing Following Tissue Trauma and Aesthetic Procedures: A Case Series
Open accessAbstract
BACKGROUND: In the aesthetics practice, measures to accelerate wound healing and minimize downtime following procedures have been largely restricted to topical serums and platelet-rich plasma (PRP), which can have varying levels of success. Here, the authors present a case series of patients treated in clinical practice with cell-free exosomes derived from human placental mesenchymal stem cells (Exovex, Exocelbio, Doylestown, PA). Topical administration of exosomes after either aesthetic treatment or traumatic injury (a dog bite) had a marked effect on healing. Effects were assessed visually, and case-study images are shared. Individuals demonstrated significantly accelerated recovery and wound healing within hours to days, depending on the procedure. Patients who had undergone the same aesthetic procedure prior without exosomes reported satisfaction with reductions in pain, swelling, redness, and post-procedure downtime. No adverse events were reported by patients after treatment. Together, these case series suggest that exosome treatment can accelerate wound healing safely and effectively and support topical use in an office-based setting. These findings also highlight the need for more formal evaluation of the effects of exosomes on wound healing in reducing aesthetic procedure recovery times for surgical and non-surgical interventions. Significant Finding: The case series presented here illustrates the potential for exosomes to be a versatile and important part of clinical care, especially in situations where expedited healing is central to patient safety and/or satisfaction. These results provide strong support for additional research. Meaning: Topical administration of cell-free exosomes has the potential to improve patient care and satisfaction with aesthetic interventions. Early experience, illustrated by the presented case studies, has been remarkably positive and treatment has the potential to dramatically improve the standard of care. Online ahead of print.
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“More recent clinical studies using topical MSC-derived or platelet-derived EVs have reported accelerated wound healing, improved texture, reduced erythema, and increased collagen synthesis [24,25].”
From A 28-Day Pilot Study of the Effects on Facial Skin Hydration, Elasticity, and Texture of a Centella asiatica Extracellular Vesicle-Based Skin Care Formulation (2025) · cites this paper as [25]
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Cites
Extracellular vesicles as drug delivery systems: Why and how?
Elsharkasy, O. M., Nordin, J. Z., Hagey, D. W., de Jong, O. G., Schiffelers, R. M., Andaloussi, S. E., & Vader, P. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.004 · Cited by 1,250
Deatherage, B. L., & Cookson, B. T. (2012) · Infection and Immunity · doi:10.1128/iai.06014-11 · Cited by 765
Ha, D. H., Kim, H.-K., Lee, J., Kwon, H. H., Park, G., Yang, S. H., Jung, J. Y., Choi, H., Lee, J. H., Sung, S., et al. (2020) · Cells · doi:10.3390/cells9051157 · Cited by 561
Exosomes and Their Therapeutic Potentials of Stem Cells
Han, C., Sun, X., Liu, L., Jiang, H., Shen, Y., Xu, X., Li, J., Zhang, G., Huang, J., Lin, Z., et al. (2015) · Stem Cells International · doi:10.1155/2016/7653489 · Cited by 249
Systematic review of the use of platelet‐rich plasma in aesthetic dermatology
Leo, M. S., Kumar, A. S., Kirit, R., et al. (2015) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.12167 · Cited by 187
The novel mechanisms and applications of exosomes in dermatology and cutaneous medical aesthetics
Xiong, M., Zhang, Q., Hu, W., Zhao, C., Lv, W., Yi, Y., Wang, Y., Tang, H., Wu, M., & Wu, Y. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105490 · Cited by 165
Jones, C. I. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9629-8 · Cited by 134
Duan, M., Zhang, Y., Zhang, H., Meng, Y., Qian, M. D., & Zhang, G. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01971-6 · Cited by 125
O’Donnell, C. T., Migliore, E., Grandi, F. C., Koltsov, J. C. B., Lingampalli, N., Cisar, C., Indelli, P. F., Sebastiano, V., Robinson, W. H., Bhutani, N., et al. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24322 · Cited by 60
Zeng, Q.-L., & Liu, D. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i22.6218 · Cited by 58
Cited by
Chang, T.-M., Wu, C.-C., Huang, H.-C., Lu, J.-Y., Chuang, C.-H., Kao, P.-L., Tang, W.-H., Liu, L. T.-C., Qiu, W.-Y., Percec, I., et al. (2025) · Cosmetics · doi:10.3390/cosmetics12050186 · Cited by 7
Metadata
- Authors
- Peredo, M., & Shivananjappa, S.
- Affiliations
- Mount Sinai Hospital (US)
- Venue
- Journal of Drugs in Dermatology
- Publisher
- SanovaWorks
- Published
- 2024-03-01
- Volume
- 23
- Issue
- 4
- Pages
- 281-284
- ISSN
- 1545-9616 (ISSN-L)
- OpenAlex
- W4394762494
- Cited by
- 21
- References
- 12
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 2
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Drugs in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- human placental mesenchymal stem cells, wound healing acceleration, cosmetic procedures, dog bites, tissue trauma
- MeSH terms
- Acceleration, Animals, Dogs, Female, Humans, Placenta, Pregnancy, Wound Healing, Exosomes, Mesenchymal Stem Cells
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