Factors Influencing the Loss of β-Cell Mass in Islet Transplantation
Open accessAbstract
Recent advances in clinical islet transplantation have clearly demonstrated that this procedure can provide excellent glycemic control and often insulin independence in a population of patients with type 1 diabetes. A key limitation in the widespread application of clinical islet transplantation is the requirement of 10,000 islet equivalents/kg in most recipients, generally derived from two or more cadaveric donors. It has been determined that a majority of the transplanted islets fail to engraft and become fully functional. In this review article, the factors that contribute to this early loss of islets following transplantation are discussed in depth.
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Discovering new ways to further address the acute stressors experienced by islets in the immediate aftermath of transplantation could further reduce the degree of β cell loss and dysfunction that impedes long-term restoration of normoglycemia.
“Discovering new ways to further address the acute stressors experienced by islets in the immediate aftermath of transplantation could further reduce the degree of β cell loss and dysfunction that impedes long-term restoration of normoglycemia.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [126]
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- Authors
- Emamaullee, J. A., & Shapiro, A. M. J.
- Affiliations
- University of Alberta (CA)
- Venue
- Cell Transplantation
- Publisher
- SAGE Publications
- Published
- 2007-01
- Volume
- 16
- Issue
- 1
- Pages
- 1-8
- ISSN
- 0963-6897 (ISSN-L)
- 1555-3892
- OpenAlex
- W2315999720
- Cited by
- 172
- References
- 75
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 2 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 12 · 2018: 12 · 2017: 13 · 2016: 11 · 2015: 3 · 2014: 11 · 2013: 6 · 2012: 11
- FWCI
- 14.28
- Type
- journal article
- Language
- en
- Open access
- green
- doaj.org
- Locations
- Cell Transplantation (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- islet transplantation, beta-cell mass loss, islet engraftment, type 1 diabetes, islet equivalents, insulin independence, glycemic control
- MeSH terms
- Cell Survival, Diabetes Mellitus, Type 1, Humans, Reperfusion Injury, Cell Hypoxia, Islets of Langerhans Transplantation, Insulin-Secreting Cells
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