The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
The effects of physical exercise on fatty liver disease.
Open accessAbstract
The increasing prevalence of obesity has made nonalcoholic fatty liver disease (NAFLD) the most common chronic liver disease. As a consequence, NAFLD and especially its inflammatory form nonalcoholic steatohepatitis (NASH) are the fastest increasing etiology of end-stage liver disease and hepatocellular carcinoma. Physical inactivity is related to the severity of fatty liver disease irrespective of body weight, supporting the hypothesis that increasing physical activity through exercise can improve fatty liver disease. This review summarizes the evidence for the effects of physical exercise on NAFLD and NASH. Several clinical trials have shown that both aerobic and resistance exercise reduce the hepatic fat content. From clinical and basic scientific studies, it is evident that exercise affects fatty liver disease through various pathways. Improved peripheral insulin resistance reduces the excess delivery of free fatty acids and glucose for free fatty acid synthesis to the liver. In the liver, exercise increases fatty acid oxidation, decreases fatty acid synthesis, and prevents mitochondrial and hepatocellular damage through a reduction of the release of damage-associated molecular patterns. In conclusion, physical exercise is a proven therapeutic strategy to improve fatty liver disease.
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In the citing paper
“Physical activity has proven to be an effective intervention for treating and preventing NAFLD”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as van der Windt et al., 2018
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Citations
Cites
1 retracted
Cintra, D. E., Ropelle, E. R., Vitto, M. F., Luciano, T. F., Souza, D. R., Engelmann, J., Marques, S. D. O., Lira, F. S., Pinho, R. A., Pauli, J. R., et al. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.08.002 · Cited by 34
Retracted2011 Compendium of Physical Activities: A Second Update of Codes and MET Values
AINSWORTH, B. E., HASKELL, W. L., HERRMANN, S. D., MECKES, N., BASSETT, D. R., TUDOR-LOCKE, C., GREER, J. L., VEZINA, J., WHITT-GLOVER, M. C., & LEON, A. S. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821ece12 · Cited by 6,317
EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease
(2016) · Journal of Hepatology · doi:10.1016/j.jhep.2015.11.004 · Cited by 4,836
Chalasani, N., Younossi, Z. M., Lavine, J. E., Diehl, A. M., Brunt, E. M., Cusi, K. J., Charlton, M., & Sanyal, A. J. (2012) · Hepatology · doi:10.1002/hep.25762 · Cited by 3,854
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Sanyal, A. J., Chalasani, N., Kowdley, K. V., McCullough, A., Diehl, A. M., Bass, N. M., Neuschwander-Tetri, B. A., Lavine, J. E., Tonascia, J., Unalp, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907929 · Cited by 3,327
Vilar-Gomez, E., Martinez-Perez, Y., Calzadilla-Bertot, L., Torres-Gonzalez, A., Gra-Oramas, B., Gonzalez-Fabian, L., Friedman, S. L., Diago, M., & Romero-Gomez, M. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.005 · Cited by 2,492
Neuschwander-Tetri, B. A., Loomba, R., Sanyal, A. J., Lavine, J. E., Van Natta, M. L., Abdelmalek, M. F., Chalasani, N., Dasarathy, S., Diehl, A. M., Hameed, B., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61933-4 · Cited by 2,237
Williams, C. D., Stengel, J. Z., Asike, M., Torres, D. M., Shaw, J. C., Contreras, M., Landt, C. L., & Harrison, S. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.038 · Cited by 2,182
Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities
Sanyal, A. J., Campbell–Sargent, C., Mirshahi, F., Rizzo, W. B., Contos, M. J., Sterling, R. K., Luketic, V. A., Shiffman, M. L., & Clore, J. N. (2001) · Gastroenterology · doi:10.1053/gast.2001.23256 · Cited by 2,078
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
Promrat, K., Kleiner, D. E., Niemeier, H. M., Jackvony, E., Kearns, M., Wands, J. R., Fava, J. L., & Wing, R. R. (2010) · Hepatology · doi:10.1002/hep.23276 · Cited by 1,330
Cited by
Sorted by citations
Sheka, A. C., Adeyi, O. A., Thompson, J., Hameed, B., Crawford, P. A., & Ikramuddin, S. (2020) · JAMA · doi:10.1001/jama.2020.2298 · Cited by 1,421
NAFLD: Mechanisms, Treatments, and Biomarkers
Nassir, F. (2022) · Biomolecules · doi:10.3390/biom12060824 · Cited by 452
Farzanegi, P., Dana, A., Ebrahimpoor, Z., Asadi, M., & Azarbayjani, M. A. (2019) · European Journal of Sport Science · doi:10.1080/17461391.2019.1571114 · Cited by 386
Exercise adaptations: molecular mechanisms and potential targets for therapeutic benefit
McGee, S. L., & Hargreaves, M. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0377-1 · Cited by 226
Diet and Non-Alcoholic Fatty Liver Disease: The Mediterranean Way
Abenavoli, L., Boccuto, L., Federico, A., Dallio, M., Loguercio, C., Renzo, L. D., & LORENZO, A. D. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16173011 · Cited by 123
Metadata
- Authors
- van der Windt, D. J., Sud, V., Zhang, H., Tsung, A., & Huang, H.
- Affiliations
- Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
- University of Pittsburgh Medical Center (US)
- Venue
- Gene Expression
- Publisher
- Xia & He Publishing
- Published
- 2018-05-18
- Volume
- 18
- Issue
- 2
- Pages
- 89-101
- ISSN
- 1052-2166 (ISSN-L)
- PMC
- PMC5954622
- OpenAlex
- W2774108532
- Cited by
- 294
- References
- 114
- Citations by year
- 2026: 19 · 2025: 37 · 2024: 40 · 2023: 39 · 2022: 36 · 2021: 61 · 2020: 42 · 2019: 17 · 2018: 3
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gene Expression (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA214865)
- National Institute of Allergy and Infectious Diseases (T32AI074490)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Keywords
- physical activity, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, aerobic exercise, resistance training, hepatic fat content, insulin resistance, fatty acid oxidation, mitochondrial damage, hepatocyte injury, damage-associated molecular patterns, obesity, end-stage liver disease, hepatocellular carcinoma
- MeSH terms
- Animals, Energy Metabolism, Exercise Therapy, Humans, Insulin, Lipid Metabolism, Non-alcoholic Fatty Liver Disease
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