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Cited by 188Gastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studiesGastrointestinal motility and disorders

The DOI matches its Crossref record; 45 of the 46 references it cites were found in a registry or an index.

Epidemiology of gastroesophageal reflux disease: A general population-based study in Xi’an of Northwest China

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Wang, Jin-Hai·2004·World Journal of Gastroenterology
DOI 10.3748/wjg.v10.i11.1647PMC PMC4572771
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Abstract

AIM: Gastroesophageal reflux disease (GERD) is a common disorder in the Western population, but detailed population-based data in China are limited. The aim of this study was to understand the epidemiology of symptomatic gastroesophageal reflux (SGER) in adults of Xi'an, a northwestern city of China, and to explore the potential risk factors of GERD. METHODS: Symptoms suggestive of GERD, functional dyspepsia (FD), irritable bowel syndrome (IBS), upper respiratory diseases and some potential risk factors were investigated in a face-to-face manner in a region-stratified random samples of 2789 residents aged 18-70 years in Xi'an by using a standardized questionnaire. METHODS: With a response rate of 91.8%, the prevalence of SGER was 16.98% (95% CI, 14.2-18.92) in Xi'an adults, and no gender-related difference was observed (P<0.05). SGER was more common among subjects aged 30-70 years than in those aged 18-29 years (P<0.01). The prevalence of SGER in rural, urban and suburban subjects was 21.07%, 17.44% and 12.12%, respectively, and there was a significant difference between rural, urban and suburban regions (P<0.05). Compared with subjects without SGER, the prevalence of symptoms suggestive of FD and IBS, pneumonia, asthma, bronchitis, laryngitis, pharyngitis, chronic cough, wheeze, globus sensation, oral ulcer and snore was significantly increased in subjects with SGER (P<0.01). Heavy smoking (OR=5.76; CI, 3.70-6.67), heavy alcohol use (OR=2.85; CI, 1.67-4.49), peptic ulcer (OR=5.76; CI, 3.99-8.32), cerebral palsy (OR=3.97; CI, 1.97-8.00), abdominal operation (OR=2.69; CI, 1.75-4.13), obesity (OR=2.16; CI, 1.47-3.16), excessive food intake (OR=1.43; CI, 1.17-1.15), sweet food (OR=1.23; CI, 0.89-1.54), and consumption of coffee (OR=1.23; CI, 0.17-2.00) were independently associated with SGER. The episodes of GERD were commonly precipitated by dietary factors (66.05%), followed by body posture (26.54%), ill temper (23.72%), fatigue (22.32%) and stress (10.93%). CONCLUSION: GERD is common in Xi'an's adult population with a mild or moderate degree. The etiology and pathogenesis of GERD are probably associated with FD, IBS, and some respiratory, laryngopharyngeal and odontostological diseases or symptoms. Some lifestyles, diseases and dietary factors are the risk factors of GERD.

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Metadata

Authors
Wang, J.-H.
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2004
Volume
10
Issue
11
Pages
1647
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v10.i11.1647
PMC
PMC4572771
OpenAlex
W2165747149
Cited by
188
References
46
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 29 · 2020: 2 · 2019: 11 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 7 · 2013: 13 · 2012: 11
FWCI
7.64
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
gastroesophageal reflux disease, prevalence, risk factors, smoking, alcohol consumption, peptic ulcer, obesity, functional dyspepsia, irritable bowel syndrome, upper respiratory symptoms, urban-rural differences, Xi'an, adults, China, global burden of disease, disability-adjusted life years, quality of life, health-related quality of life
MeSH terms
Adolescent, Adult, Aged, China, Female, Gastroesophageal Reflux, Humans, Laryngitis, Lung Diseases, Male, Middle Aged, Pharyngitis, Surveys and Questionnaires, Risk Factors, Rural Population, Urban Population, Prevalence, Age Distribution, Sex Distribution

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