The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
Immunopathology of inflammatory bowel disease
Open accessAbstract
Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. The host microbiome, as well as viruses and fungi, play important roles in the development of IBD either by causing inflammation directly or indirectly through an altered immune system. New technologies have allowed researchers to be able to quantify the various components of the microbiome, which will allow for future developments in the etiology of IBD. Various components of the mucosal immune system are implicated in the pathogenesis of IBD and include intestinal epithelial cells, innate lymphoid cells, cells of the innate (macrophages/monocytes, neutrophils, and dendritic cells) and adaptive (T-cells and B-cells) immune system, and their secreted mediators (cytokines and chemokines). Either a mucosal susceptibility or defect in sampling of gut luminal antigen, possibly through the process of autophagy, leads to activation of innate immune response that may be mediated by enhanced toll-like receptor activity. The antigen presenting cells then mediate the differentiation of naïve T-cells into effector T helper (Th) cells, including Th1, Th2, and Th17, which alter gut homeostasis and lead to IBD. In this review, the effects of these components in the immunopathogenesis of IBD will be discussed.
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Cites
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NF-κB signaling in inflammation
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From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
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Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature Reviews Immunology · doi:10.1038/nri3738 · Cited by 1,756
An Overview of the Mechanism of Action of the Monoclonal Antibody Vedolizumab
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The emerging role of oxidative stress in inflammatory bowel disease
Muro, P., Zhang, L., Li, S., Zhao, Z., Jin, T., Mao, F., & Mao, Z. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1390351 · Cited by 279
Metadata
- Authors
- Wallace, K. L.
- Venue
- World Journal of Gastroenterology
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 20
- Issue
- 1
- Pages
- 6
- ISSN
- 1007-9327 (ISSN-L)
- OpenAlex
- W2072907428
- Cited by
- 579
- References
- 163
- FWCI
- 29.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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