Cited by 322Hepatitis B Virus StudiesHepatitis C virus researchHepatitis Viruses Studies and Epidemiology

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Hepatitis B virus burden in developing countries

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Zampino, Rosa·2015·World Journal of Gastroenterology

DOI 10.3748/wjg.v21.i42.11941PMC PMC4641116

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Abstract

Hepatitis B virus (HBV) infection has shown an intermediate or high endemicity level in low-income countries over the last five decades. In recent years, however, the incidence of acute hepatitis B and the prevalence of hepatitis B surface antigen chronic carriers have decreased in several countries because of the HBV universal vaccination programs started in the nineties. Some countries, however, are still unable to implement these programs, particularly in their hyperendemic rural areas. The diffusion of HBV infection is still wide in several low-income countries where the prevention, management and treatment of HBV infection are a heavy burden for the governments and healthcare authorities. Of note, the information on the HBV epidemiology is scanty in numerous eastern European and Latin-American countries. The studies on molecular epidemiology performed in some countries provide an important contribution for a more comprehensive knowledge of HBV epidemiology, and phylogenetic studies provide information on the impact of recent and older migratory flows.

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Authors: Zampino, R.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
Corresponding author: Zampino, Rosa
ORCID: Zampino, Rosa
Venue: World Journal of Gastroenterology
Publisher: Baishideng Publishing Group Inc.
Published: 2015
Volume: 21
Issue: 42
Pages: 11941
ISSN: 1007-9327 (ISSN-L)
DOI: 10.3748/wjg.v21.i42.11941
PMC: PMC4641116
OpenAlex: W2176322681
Cited by: 322
References: 177
Citations by year: 2026: 7 · 2025: 27 · 2024: 36 · 2023: 48 · 2022: 41 · 2021: 41 · 2020: 28 · 2019: 33 · 2018: 33 · 2017: 23 · 2016: 5
FWCI: 2.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Gastroenterology (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
World Journal of Gastroenterology
Funders: World Health Organization
Centers for Disease Control and Prevention
Topics: Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Hepatology › Hepatitis Viruses Studies and Epidemiology
Keywords: hepatitis B virus, HBV endemicity, low-income countries, hepatitis B vaccination program, chronic HBsAg carriers, HBV epidemiology, molecular epidemiology, phylogenetic analysis, healthcare burden
MeSH terms: Acute Disease, Africa, Asia, Developing Countries, Europe, Hepatitis B, Humans, Latin America, Prognosis, Risk Factors, Time Factors, Incidence, Prevalence, Molecular Epidemiology, Hepatitis B, Chronic

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Hepatitis B virus burden in developing countries

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