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Cited by 20Celiac Disease Research and ManagementVaccine Coverage and HesitancyImmune responses and vaccinations

Immune response to vaccines in children with celiac disease

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Anania, Caterina, Olivero, Francesca, Spagnolo, Alessandra, Chiesa, Claudio, Pacifico, Lucia·2017·World Journal of Gastroenterology
DOI 10.3748/wjg.v23.i18.3205PMC PMC5434426
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Abstract

Celiac disease (CD) is an immune-mediated systemic condition evoked by ingestion of gluten and related prolamines in genetically susceptible subjects. The disease is featured by a variable combination of clinical signs, specific antibodies, HLA-DQ2 and HLA-DQ8 haplotypes, and enteropathy. Vaccination is the most potent intervention for infectious disease prevention. Several factors including age, gender, ethnicity, quality and quantity of vaccine antigen, doses, and route of administration can influence immune response to vaccination, although the main cause of variation in the responsiveness among vaccine recipients is host genetic variability. The HLA system has a fundamental role in identifying the antigens introduced into the host with the vaccines and in the development of specific antibodies, and some HLA phenotypes have been associated with a less effective immunological response. The available literature indicates that the immunological response to vaccines in CD children does not differ markedly from that of general population and antibody titres are high enough to provide long-term protection, except for hepatitis B virus vaccine. In this article, we review and discuss the scarce literature in this field in order to provide clinical practice guidelines to achieve the most efficient monitoring of the response to vaccines in pediatric CD patients.

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  • HBV vaccine has been shown to potentially have a reduced response, with 50% of patients with coeliac disease having a poor antibody response vs. 11% of controls in case of vaccination within the first 6 months of life.

    “Concerning immunization, HBV vaccine has been shown to potentially have a reduced response, with 50% of patients with CD having a poor antibody response vs. 11% of controls in case of vaccination within the first 6 months of life (41-43).”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [43]

    The ‘Responses to vaccinations in children with celiac disease’ section reports that 50% of children with celiac disease and 11.6% of controls were non-responders to HBV vaccination, supporting the approximate comparison. It does not say that these figures apply specifically to vaccination within the first six months of life; its discussion of infant vaccination schedules concerns a different study. (LLM, conf=0.88)

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  • A second dose effectively induces protective levels in those coeliac disease children.

    “A second dose effectively induces protective levels in those CD children (41-44).”

    From ESPGHAN Position Paper on Management and Follow-up of Children and Adolescents With Celiac Disease. (2022) · cites this paper as [43]

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Research works printed but not linked: 53

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Authors
Anania, C., Olivero, F., Spagnolo, A., Chiesa, C., & Pacifico, L.
Affiliations
Policlinico Umberto I (IT)
ORCID
Venue
World Journal of Gastroenterology
Publisher
Baishideng Publishing Group Inc.
Published
2017
Volume
23
Issue
18
Pages
3205
ISSN
1007-9327 (ISSN-L)
DOI
10.3748/wjg.v23.i18.3205
PMC
PMC5434426
OpenAlex
W2613560805
Cited by
20
References
61
Citations by year
2024: 3 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2
FWCI
0.37
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • World Journal of Gastroenterology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by-nc)
Topics
  • Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
celiac disease, vaccine immunogenicity, children, HLA-DQ2, HLA-DQ8, hepatitis B vaccine, host genetic variation, vaccine response monitoring
MeSH terms
Adolescent, Celiac Disease, Child, Child, Preschool, Female, Glutens, Haplotypes, HLA-DQ Antigens, Humans, Immune System, Infant, Male, Phenylpropanolamine, Risk, Vaccination, Hepatitis B Vaccines, Practice Guidelines as Topic, Diet, Gluten-Free

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