A mixed model approach for intent-to-treat analysis in longitudinal clinical trials with missing values

Chakraborty, Hrishikesh

doi:10.3768/rtipress.2009.mr.0009.0903

A mixed model approach for intent-to-treat analysis in longitudinal clinical trials with missing values

Missing values and dropouts are common issues in longitudinal studies in all areas of medicine and public health. Intent-to-treat (ITT) analysis has become a widely accepted method for the analysis of controlled clinical trials. In most controlled clinical trials, some patients do not complete th…