The neuroprotective roles of BDNF in hypoxic ischemic brain injury
Open accessAbstract
Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation. Hypothermia and erythropoietin (EPO) have long been known to be neuroprotective in ischemic brain injury. Brain-derived neurotrophic factor (BDNF) has recently been recognized as a potent modulator capable of regulating a wide repertoire of neuronal functions. This review was based on studies concerning the involvement of BDNF in the protection of H/I brain injury following a search in PubMed between 1995 and December, 2011. We initially examined the background of BDNF, and then focused on its neuroprotective mechanisms against ischemic brain injury, including its involvement in promoting neural regeneration/cognition/memory rehabilitation, angiogenesis within ischemic penumbra and the inhibition of the inflammatory process, neurotoxicity, epilepsy and apoptosis. We also provided a literature overview of experimental studies, discussing the safety and the potential clinical application of BDNF as a neuroprotective agent in the ischemic brain injury.
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BDNF exerts positive effects such as anti-apoptosis, anti-inflammation, anti-neurotoxicity and neural regeneration.
“It is known that BDNF exerts positive effects such as anti-apoptosis, anti-inflammation, anti-neurotoxicity and neural regeneration.”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [100]
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References 99 · Cited by 267
- Authors
- CHEN, A., XIONG, L.-J., TONG, Y., & MAO, M.
- Affiliations
- Sichuan University (CN)
- Venue
- Biomedical Reports
- Publisher
- Spandidos Publications
- Published
- 2012-12-14
- Volume
- 1
- Issue
- 2
- Pages
- 167-176
- ISSN
- 2049-9434 (ISSN-L)
- 2049-9442
- PMC
- PMC3956206
- OpenAlex
- W2075992165
- Cited by
- 267
- References
- 99
- Citations by year
- 2026: 4 · 2025: 14 · 2024: 30 · 2023: 24 · 2022: 17 · 2021: 20 · 2020: 27 · 2019: 14 · 2018: 34 · 2017: 23 · 2016: 17 · 2015: 28 · 2014: 12 · 2013: 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biomedical Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30973215)
- Program for Changjiang Scholars and Innovative Research Team in University
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- brain-derived neurotrophic factor, hypoxic-ischemic brain injury, neuroprotection, ischemic penumbra, angiogenesis, neuroinflammation, neurotoxicity, epilepsy, apoptosis, neonatal brain injury
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