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Age reprogramming: Innovations and ethical considerations for prolonged longevity (Review)
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If powerful and costly interventions are accessible only to the wealthy, they could create a "longevity dividend", exacerbating existing social and health inequities.
“If such powerful and costly interventions are accessible only to the wealthy, they could create a “longevity dividend”, exacerbating existing social and health inequities.”
From Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming (2026) · cites this paper as [138]
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Citations
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Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · cited 1×
“For example, modifying pathways involved in T‑cell regeneration or reducing pro‑inflammatory cytokines could enhance immune resilience in older adults (76).”
Macip, C. C., Hasan, R., Hoznek, V., Kim, J., Lu, Y. R., Metzger, L. E., Sethna, S., & Davidsohn, N. (2024) · Cellular Reprogramming · doi:10.1089/cell.2023.0072 · Cited by 95 · cited 1×
“Yamanaka factors have shown great potential for reversing cellular aging, but future efforts should focus on refining these tools to achieve controlled and reversible reprogramming without inducing tumorigenicity or loss of cell identity (74,75).”
Macip, C. C., Hasan, R., Hoznek, V., Kim, J., Metzger, L. E., Sethna, S., & Davidsohn, N. (2023) · doi:10.1101/2023.01.04.522507 · Cited by 95
The NuRD complex cooperates with SALL4 to orchestrate reprogramming
Wang, B., Li, C., Ming, J., Wu, L., Fang, S., Huang, Y., Lin, L., Liu, H., Kuang, J., Zhao, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38543-0 · Cited by 39 · cited 1×
“The study by Wang et al (26) on the nucleosome remodeling deacetylase (NuRD) complex and spalt like transcription factor 4 (Sall4) further enriches our understanding of chromatin remod‑ eling during early reprogramming (26).”
Novel human iPSC models of neuroinflammation in neurodegenerative disease and regenerative medicine
Summers, R. A., Fagiani, F., Rowitch, D. H., Absinta, M., & Reich, D. S. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.004 · Cited by 39
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Cited by
Sorted by citations
Emerging strategies in senotherapeutics: from broad-spectrum senolysis to precision reprogramming
Zhang, W., Song, S., Zhang, Y., Pan, Y., Hu, D., & Wang, Y. (2026) · npj Aging · doi:10.1038/s41514-026-00355-z · Cited by 6
Metadata
- Authors
- Saliev, T., & Singh, P.
- Venue
- Biomedical Reports
- Publisher
- Spandidos Publications
- Published
- 2025-04-10
- Volume
- 22
- Issue
- 6
- Pages
- 1-15
- ISSN
- 2049-9434
- 2049-9442
- PMC
- PMC12035601
- Cited by
- 14
- References
- 5
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