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Cited by 47Heat shock proteins researchLung Cancer Research StudiesBreast Cancer Treatment Studies

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Prognostic value of the mRNA expression of members of the HSP90 family in non‑small cell lung cancer

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Liu, Kang, Kang, Min, Li, Jixi, Qin, Wen, Wang, Rensheng·2019·Experimental and Therapeutic Medicine
DOI 10.3892/etm.2019.7228PMC PMC6425268
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Abstract

The aim of the present study was to investigate the potential prognostic value of members of the heat shock protein (HSP)90 family in non-small cell lung cancer (NSCLC) patients. The mRNA expression profiles of 1,926 NSCLC patients, which was available from the Kaplan-Meier plotter database, were included in the study. High expression of HSP90AA1 mRNA was significantly associated with a poorer rate of overall survival (OS) for all NSCLC patients [hazard ratio (HR), 1.21; 95% confidence interval (CI): 1.06-1.37; P=0.004], as well as for patients with adenocarcinoma (ADE; HR, 1.3; 95% CI: 1.02-1.65; P=0.034), but no significant correlation was identified for squamous cell carcinoma (SCC) patients (HR, 1.08; 95% CI: 0.85-1.38; P=0.51). High expression of HSP90AB1 and HSP90B1 mRNA was significantly associated with poorer rates of OS in lung SCC and ADE patients combined, as well as in lung ADE patients alone. By contrast, high expression of tumor necrosis factor receptor-associated protein 1 (TRAP1) mRNA was significantly associated with improved OS rates in all NSCLC patients combined (HR, 0.88; 95% CI: 0.77-0.99; P=0.041), as well as ADE patients. In stratified survival analysis, a high expression of HSP90AA1, HSP90AB1 and HSP90B1 predicted poor prognosis in stage I NSLCC patients, suggesting that these genes may serve as stage-independent prognostic indicators. As an elevated expression of HSP90AA1, HSP90AB1, HSP90B1 and TRAP1 was associated with poorer OS outcomes in patients with NSCLC, these HSP90 members may be potential prognostic biomarkers and drug targets for the treatment of NSCLC.

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  • HSP90AB1 facilitates tumorigenesis in a spectrum of cancers, including gastric cancer, breast cancer, NSCLC, hepatocellular carcinoma, and head and neck squamous cell carcinoma.

    “Multiple investigations have revealed that HSP90AB1 facilitates tumorigenesis in a spectrum of cancers, including gastric cancer, breast cancer, non-small cell lung cancer (NSCLC), hepatocellular carcinoma, and head and neck squamous cell carcinoma [13–18].”

    From Celastrol attenuates the invasion and migration and augments the anticancer effects of olaparib in prostate cancer (2024) · cites this paper as [15]

    The Discussion reports that high HSP90AB1 mRNA expression was associated with poorer overall survival in patients with lung adenocarcinoma, a type of NSCLC, but not in patients with squamous cell carcinoma. It does not establish that HSP90AB1 facilitates tumorigenesis; the authors say further research is needed to explore the underlying mechanisms. No page number is available in our copy. (LLM, conf=0.88)

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Metadata

Authors
Liu, K., Kang, M., Li, J., Qin, W., & Wang, R.
Affiliations
First Affiliated Hospital of GuangXi Medical University (CN)
Corresponding author
Wang, Rensheng
ORCID
Venue
Experimental and Therapeutic Medicine
Publisher
Spandidos Publications
Published
2019-01-31
Volume
17
Issue
4
Pages
2657-2665
ISSN
  • 1792-0981 (ISSN-L)
  • 1792-1015
DOI
10.3892/etm.2019.7228
PMC
PMC6425268
OpenAlex
W2913876929
Cited by
47
References
1
Citations by year
2026: 2 · 2025: 4 · 2024: 5 · 2023: 14 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 2
FWCI
1.61
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Experimental and Therapeutic Medicine (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81460460, 81360405, 81760542)
  • China Postdoctoral Science Foundation (2016M602918XB)
  • Science and Technology Department of Guangxi Zhuang Autonomous (2016GXNSFAA380252, 2014GXNSFBA118114)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
non-small cell lung cancer, HSP90AA1, HSP90AB1, HSP90B1, TRAP1, mRNA expression, prognostic factors, overall survival, adenocarcinoma, squamous cell carcinoma, therapeutic target

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