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Cited by 6Liver physiology and pathologyLiver Disease and TransplantationOrgan Transplantation Techniques and Outcomes

A preliminary study of associating liver partition and portal vein ligation for staged hepatectomy in a rat model of liver cirrhosis

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Yang, Xianwei, Yang, Chuang, Qiu, Yiwen, Shen, Shu, Kong, Junjie, Wang, Wentao·2019·Experimental and Therapeutic Medicine
DOI 10.3892/etm.2019.7688PMC PMC6601136
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Abstract

Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in a rat model of liver cirrhosis has not, to the best of our knowledge, been previously investigated. The present study therefore aimed to establish a model of ALPPS in cirrhotic rats and to assess liver regeneration. Rats were randomly divided into an ALPPS group with carbon tetrachloride-induced cirrhosis (group A) and a normal liver (group B). Rat weight, cytokine levels, biochemical parameters and histopathology were assessed 1, 2, 3, 7 and 14 days after ALPPS. Higher aspartate aminotransferase and alanine aminotransferase levels were detected in group A on the first postoperative day. On the first, second and third days, hepatocyte proliferation rate was higher in group B than in group A. After 3 days, hepatocyte proliferation rate in group B began to decrease, but the rate in group A continued to increase until the 14th day. Higher levels of hepatocyte growth factor, interleukin-6 and tumor necrosis factor-α were detected in group A compared with group B, but the differences were not significant. The present study demonstrated that ALPPS promoted liver regeneration in a rat model of cirrhosis, but significantly impaired liver function. Compared with the ALPPS model, group B exhibited a delayed peak of proliferation. The mechanism of liver regeneration induced by ALPPS in cirrhotic rats may be associated with increased cytokine levels.

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  • Liver regeneration under ALPPS occurs significantly faster compared to standard hepatectomy.

    “Research has shown that LR under conditions occurs significantly faster compared to standard hepatectomy[32].”

    From Liver regeneration after partial hepatectomy: Triggers and mechanisms (2025) · cites this paper as [32]

    The Discussion reports significantly faster liver regeneration after ALPPS than after portal vein ligation (PVL) in earlier animal studies. The Introduction likewise says ALPPS increases future liver volume sooner than PVL or portal vein embolization. Neither passage compares ALPPS with standard hepatectomy, so the stated comparator is unsupported. (LLM, conf=0.88)

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Cited by

Sorted by citations

Authors
Yang, X., Yang, C., Qiu, Y., Shen, S., Kong, J., & Wang, W.
Affiliations
West China Medical Center of Sichuan University (CN)
Corresponding author
Wang, Wentao
ORCID
Venue
Experimental and Therapeutic Medicine
Publisher
Spandidos Publications
Published
2019-06-18
Volume
18
Issue
2
Pages
1203-1211
ISSN
  • 1792-0981 (ISSN-L)
  • 1792-1015
DOI
10.3892/etm.2019.7688
PMC
PMC6601136
OpenAlex
W2950704432
Cited by
6
References
1
Citations by year
2025: 2 · 2023: 2 · 2022: 2
FWCI
0.32
Type
journal article
Language
en
Open access
Licence
cc-by-nc-nd
Locations
  • Experimental and Therapeutic Medicine (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
Department of Science and Technology of Sichuan Province (2016FZ0076)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
ALPPS, liver cirrhosis, liver regeneration, carbon tetrachloride-induced cirrhosis, hepatocyte proliferation, cytokines, hepatocyte growth factor, interleukin-6, TNF-α, liver function impairment, rat model

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