Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets
Open accessAbstract
Neuromedin U (NmU) is a regulatory peptide found in significant concentrations in both the brain and gut of the rat and is named according to its ability to powerfully contract the uterus. Two types of NmU receptors were recently identified and subsequent studies evidenced NmU involvement in the regulation of energy homeostasis. Such a role of neuromedin U suggests that a polypeptide may also be involved in the regulation of adipoinsular axis function. Therefore in the present study we examined the expression of NmU receptors in pancreatic islets using RT-PCR and Western blotting analysis. We also investigated the role of NmU in regulation of insulin secretion in vitro using isolated pancreatic islets. We have confirmed that NmUR1 but not NmUR2 is specifically expressed in isolated rat pancreatic islets. In all tested doses (1, 10, 100 nmol/l) NmU dose- dependently decreased insulin output by isolated pancreatic islets. These inhibitory effects of NmU on insulin secretion may suggest the involvement of NmU in regulating the pancreatic branch of adipoinsular axis function. Thus, NmU can be included in that group of anorectic peptides, which are also involved in the regulation of insulin secretion.
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NmU likely regulates insulin secretion; NmUR1 is expressed in pancreatic islets and its stimulation dose-dependently decreased insulin release.
“In addition to this, NmU is likely to regulate insulin secretion; the G-protein-coupled NmU receptor 1 (NmUR1) is expressed in pancreatic islets and its simulation dose dependently decreased insulin release.230, 231”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [230]
The Results report NmUR1 expression in rat pancreatic islets and a dose-dependent decrease in insulin output when isolated islets were treated with NmU. The Discussion cautions that this effect may not be directly connected to NmUR1 signaling in beta cells, so the paper does not establish that stimulation of NmUR1 itself caused the decrease. (LLM, conf=0.87)
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References 26 · Cited by 39
Research works printed but not linked: 1
- Hanada R, Teranishi H, Pearson JT, et al: Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10: 1067-1073, 2004.
- Authors
- Kaczmarek, P., Malendowicz, L., Pruszynska-Oszmalek, E., Wojciechowicz, T., Szczepankiewicz, D., Szkudelski, T., & Nowak, K.
- Affiliations
- Poznan University of Medical Sciences (PL)
- ORCID
- Venue
- International Journal of Molecular Medicine
- Publisher
- Spandidos Publications
- Published
- 2006-11-01
- Volume
- 18
- Issue
- 5
- Pages
- 951-5
- ISSN
- 1107-3756 (ISSN-L)
- 1791-244X
- OpenAlex
- W2037502126
- Cited by
- 39
- References
- 26
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 5 · 2013: 2 · 2012: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Molecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- neuromedin U, pancreatic islets, insulin secretion, energy homeostasis, anorectic peptides, endocrine pancreas, receptor expression
- MeSH terms
- Insulin Secretion, Animals, Appetite Depressants, Insulin, Insulin Antagonists, Islets of Langerhans, Membrane Proteins, Neuropeptides, RNA, Messenger, Blotting, Western, Receptors, Neurotransmitter, Reverse Transcriptase Polymerase Chain Reaction, Rats, In Vitro Techniques
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