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FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer
Abstract
FRAT1 and FRAT2 are cancer-associated genes encoding GSK-3beta-binding proteins. Over-expression of FRAT1 or FRAT2 lead to carcinogenesis through activation of WNT--beta-catenin--TCF signaling pathway. We have previously cloned and characterized FRAT2. Here, we found that FRAT1 and FRAT2 genes were clustered in the human chromosome 10q24.1 region. Blast search revealed that FRAT1 and FRAT2 genes, consisting of a single exon, were located together on human genome draft sequences AC006098.1 and AL355490.7, corresponding to the human chromosome 10q24.1 region. FRAT1 and FRAT2 genes were clustered in a tail to tail manner with an interval of about 10.7 kb. The 2.7-kb FRAT1 mRNA was relatively highly expressed in fetal brain, adult spleen, pancreas, HeLa S3 (cervical cancer), and K-562 (chronic myelogenous leukemia). FRAT1 and FRAT2 were co-expressed in 7 gastric cancer cell lines and 10 cases of primary gastric cancer, and were up-regulated together in gastric cancer cell line TMK1 and 2 cases of primary gastric cancer. These results indicated that FRAT1 and FRAT2 genes were up-regulated together in several cases of human gastric cancer. Up-regulation of FRAT1 and FRAT2 in gastric cancer might lead to carcinogenesis through activation of WNT--beta-catenin--TCF signaling pathway.
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“among which five of them (FZD7, FZD6, TCF4, FRAT2 and ARBB2) have been related to Wnt activation in cancer (20-25)”
From Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib (2012) · cites this paper as [24]
In the citing paper
“In contrast, several genes dysregulated in Wnt-TGFβ-class characterize Wnt-signaling activation in cancer (20-25) (Fig. 6).”
From Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib (2012) · cites this paper as [24]
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Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H.-W., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2322 · Cited by 306
Metadata
- Authors
- Saitoh, T., & Katoh, M.
- Affiliations
- National Cancer Center Research Institute (JP)
- ORCID
- Katoh, Masaru
- Venue
- International Journal of Oncology
- Publisher
- Spandidos Publications
- Published
- 2001-08-01
- Volume
- 19
- Issue
- 2
- Pages
- 311-5
- ISSN
- 1019-6439 (ISSN-L)
- 1791-2423
- OpenAlex
- W2087493944
- Cited by
- 40
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 3 · 2020: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Foundation for Promotion of Cancer Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Gastric Cancer Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- gene clustering, gastric cancer, gene overexpression, carcinogenesis, single-exon genes, tissue-specific gene expression
- MeSH terms
- Carrier Proteins, Chromosomes, Human, Pair 10, Female, Multigene Family, HeLa Cells, Humans, Male, Neoplasm Proteins, Proto-Oncogene Proteins, RNA, Messenger, Stomach Neoplasms, Tissue Distribution, Blotting, Northern, Up-Regulation, Gene Expression Regulation, Neoplastic, HL-60 Cells, K562 Cells, Gene Expression Profiling, Gene Order, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing
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