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Cited by 201Effects of Radiation ExposureRadiation Therapy and DosimetryDNA Repair Mechanisms

Radiation-induced signaling pathways that promote cancer cell survival (Review)

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HEIN, ASHLEY L., OUELLETTE, MICHEL M., YAN, YING·2014·International Journal of Oncology
DOI 10.3892/ijo.2014.2614PMC PMC4203326
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Abstract

Radiation therapy is a staple cancer treatment approach that has significantly improved local disease control and the overall survival of cancer patients. However, its efficacy is still limited by the development of radiation resistance and the presence of residual disease after therapy that leads to cancer recurrence. Radiation impedes cancer cell growth by inducing cytotoxicity, mainly caused by DNA damage. However, radiation can also simultaneously induce multiple pro-survival signaling pathways, such as those mediated by AKT, ERK and ATM/ATR, which can lead to suppression of apoptosis, induction of cell cycle arrest and/or initiation of DNA repair. These signaling pathways act conjointly to reduce the magnitude of radiation-induced cytotoxicity and promote the development of radioresistance in cancer cells. Thus, targeting these pro-survival pathways has great potential for the radiosensitization of cancer cells. In the present review, we summarize the current literature on how these radiation‑activated signaling pathways promote cancer cell survival.

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Cited by

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Authors
HEIN, A. L., OUELLETTE, M. M., & YAN, Y.
Affiliations
University of Nebraska Medical Center (US)
Corresponding author
  • OUELLETTE, MICHEL M.
  • YAN, YING
ORCID
Venue
International Journal of Oncology
Publisher
Spandidos Publications
Published
2014-08-20
Volume
45
Issue
5
Pages
1813-1819
ISSN
  • 1019-6439 (ISSN-L)
  • 1791-2423
DOI
10.3892/ijo.2014.2614
PMC
PMC4203326
OpenAlex
W2007263630
Cited by
201
References
5
Citations by year
2026: 13 · 2025: 11 · 2024: 16 · 2023: 8 · 2022: 20 · 2021: 31 · 2020: 15 · 2019: 22 · 2018: 17 · 2017: 20 · 2016: 23 · 2015: 5
FWCI
2.47
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Oncology (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Nebraska Department of Health and Human Services
  • National Cancer Institute (CA127297, P50CA127297)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
radiation-induced signaling, tumor cell survival, radioresistance (biology), radiosensitization, Akt signaling, ERK signaling, ATM/ATR signaling, DNA damage response, apoptosis inhibition, cell cycle arrest, DNA repair, radiotherapy
MeSH terms
Cell Survival, Cell Transformation, Neoplastic, DNA Damage, Humans, Neoplasms, Radiation Tolerance, Radiation-Sensitizing Agents, Apoptosis

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