The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Lineage infidelity and expression of melanocytic markers in human breast cancer
Open accessAbstract
In previous analyses, dual expression of melanocytic and epithelial molecular markers have been described as indicators of lineage infidelity for breast cancer cells that lose their epithelial identity. Here we demonstrated that this is a much more frequent phenomenon in human breast carcinomas, usually affecting only a part of the tumor. Accordingly we detected, in 18 out of 100 breast carcinomas, immunohistochemically focally positive cells for the melanocytic marker Melan A. The presence and extent of Melan A expression was statistically significantly associated with a reduction in tumor cell differentiation, but not tumor type, size, lymph node metastasis, hormone receptor status or Her-2-neu expression. Microarrays of a further 159 breast cancers showed, in several samples, variably low expression levels of Melan A (and other melanocytic markers) that are consistent with focal expression in many tumors. One case strongly overexpressed Melan A. The transition from an epithelial to a melanocytic phenotype (lineage infidelity) appears to occur much more frequently than previously assumed and occurs in restricted areas of breast cancer during tumor progression, a possible association with a reduction in tumor cell differentiation.
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“Similarly, breast carcinoma has been demonstrated to express melanocytic markers, with increased expression in less differentiated tumors.40”
From Authentication of M14 melanoma cell line proves misidentification of MDA‐MB‐435 breast cancer cell line (2018) · cites this paper as [40]
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Lineage infidelity in acute leukemia
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Cited by
MDA-MB-435 and M14 Cell Lines: Identical but not M14 Melanoma?
Chambers, A. F. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1528 · Cited by 218
Marcato, P., Dean, C. A., Liu, R., Coyle, K. M., Bydoun, M., Wallace, M., Clements, D. R., Turner, C., Mathenge, E. G., Gujar, S. A., et al. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.07.010 · Cited by 142
Weber, M. R., Zuka, M., Lorger, M., Tschan, M. P., Torbett, B. E., Zijlstra, A., Quigley, J. P., Staflin, K., Eliceiri, B. P., Krueger, J. S., et al. (2016) · Thrombosis Research · doi:10.1016/s0049-3848(16)30095-0 · Cited by 74
Korch, C., Hall, E. M., Dirks, W. G., Ewing, M., Faries, M., Varella‐Garcia, M., Robinson, S., Storts, D., Turner, J. A., Wang, Y., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31067 · Cited by 54
“Similarly, breast carcinoma has been demonstrated to express melanocytic markers, with increased expression in less differentiated tumors.(40) Lineage infidelity can potentially affect both breast carcinoma and melanoma cells.”
BackgroundHistological clues to the diagnosis of metastasis to the breast from extramammary malignancies
Lee, A. H. S., Hodi, Z., Soomro, I. N., Sovani, V., Abbas, A., Rakha, E. A., & Ellis, I. O. (2020) · Histopathology · doi:10.1111/his.14141 · Cited by 35
Metadata
- Authors
- Nerlich
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Nerlich
- Venue
- international Journal of Oncology
- Publisher
- Spandidos Publications
- Published
- 1992-01-01
- Volume
- 33
- Issue
- 5
- Pages
- 1011-5
- ISSN
- 1019-6439 (ISSN-L)
- OpenAlex
- W2143621188
- Cited by
- 15
- References
- 13
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Oncology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutscher Akademischer Austauschdienst
- Ministero della Salute
- Regione Liguria
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Pathology and Forensic Medicine › Breast Lesions and Carcinomas
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- breast cancer, lineage infidelity, melanocytic markers, Melan-A, tumor cell differentiation, tumor progression, gene expression profiling
- MeSH terms
- Antigens, Neoplasm, Breast Neoplasms, Carcinoma, Intraductal, Noninfiltrating, Cell Differentiation, Female, Humans, Immunohistochemistry, Melanocytes, Neoplasm Proteins, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Carcinoma, Ductal, Breast, Cell Lineage, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MART-1 Antigen
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- The paper
- Nerlich. (1992). Lineage infidelity and expression of melanocytic markers in human breast cancer. international Journal of Oncology. https://doi.org/10.3892/ijo_00000089
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
