The regulatory role of Fos related antigen‑1 in inflammatory bowel disease
Open accessAbstract
The etiology of inflammatory bowel disease (IBD) remains unclear. The ratio of Fos related antigen‑1 (Fra‑1)‑positive intestinal mucosa epithelial cells is significantly increased in active IBD. This study intends to explore the regulatory role of Fra‑1 in IBD. The Fra‑1 eukaryotic expression vector was constructed and stably transfected to establish the Fra‑1 overexpression HCT‑116 (116‑Fra‑1) intestinal epithelial cell line. The impact of Fra‑1 overexpression on intestinal mucosal epithelial cell damage repair function was tested using a scratch assay. The role of Fra‑1 overexpression on intestinal mucosal epithelial cell proliferation was evaluated using a Cell Counting Kit-8 assay. Apoptosis related proteins, B‑cell lymphoma 2 (Bcl‑2), c‑Myc, Survivin and Bcl‑extra large (Bcl‑xL), expression levels were detected by western blotting. Fra‑1 suppressed intestinal mucosal epithelial cell damage repair and proliferation. Fra‑1 inhibited the protein levels of Bcl‑2, c‑Myc, Survivin, and Bcl‑xL. Fra‑1 overexpression in intestinal mucosal epithelial cells may restrain damage repair after intestinal mucosal injury in IBD remittent period through weakening the protective effect of intestinal mucosa, thus increasing the risk of recurrence. Therefore, suppressing Fra‑1 expression in intestinal mucosal epithelial cells may contribute to IBD remittent maintenance and recurrence delay.
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These TFs have been previously reported to be associated with IBD in the literature.
“These TFs have been previously reported to be associated with IBD in the literature.”
From Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data (2025) · cites this paper as [66]
The Introduction reports an association between Fra-1 expression in intestinal epithelial cells and IBD activity, and the Discussion reports elevated STAT1, STAT6 and CREB signaling in IBD patients. The citing sentence does not identify which transcription factors “these TFs” refers to, so this paper cannot verify the claim for the entire unspecified group. (LLM, conf=0.78)
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Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data
Yuan, Q., & Duren, Z. (2025) · Nature Biotechnology · doi:10.1038/s41587-024-02182-7 · Cited by 118 · see citing works
“Finally, we extracted the sub-network of the eight candidate TFs from the classical monocyte trans -regulatory network for IBD (Fig.”
Influential
- Authors
- Wang, X., Guo, R., Lv, Y., & Fu, R.
- Affiliations
- Shandong University (CN)
- Taian City Central Hospital (CN)
- Second Hospital of Shandong University (CN)
- Venue
- Molecular Medicine Reports
- Publisher
- Spandidos Publications
- Published
- 2017-11-15
- Volume
- 17
- Issue
- 1
- Pages
- 1979-1985
- ISSN
- 1791-2997 (ISSN-L)
- 1791-3004
- OpenAlex
- W2768118760
- Cited by
- 11
- References
- 0
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Medicine Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- Fos-related antigen 1, inflammatory bowel disease, intestinal epithelial cells, epithelial repair, cell proliferation, apoptosis, Bcl-2, c-Myc, survivin, Bcl-xL, recurrence, HCT116 cells
- MeSH terms
- Fos-Related Antigen 1, Humans, Intestinal Mucosa, Inflammatory Bowel Diseases, Up-Regulation, Proto-Oncogene Proteins c-fos, Apoptosis, HCT116 Cells, Cell Proliferation
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