Expression of VEGF and MMP-9 and MRI imaging changes in cerebral glioma
Open accessAbstract
The purpose of the present study was to investigate the association of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) expression with the histopathological grading of tumors in cerebral glioma. A total of 45 patients with pathologically confirmed cerebral glioma were divided into two groups: a low-grade group (grades I and II, 21 cases) and a high-grade group (grades III and IV, 24 cases). Immunohistochemical staining of tumor samples showed the percentages of tumors expressing VEGF and MMP-9 in the high-grade group to be 95.83 and 75%, respectively, significantly higher than those of the low-grade group (66.67 and 23.81%, P<0.05 and P<0.01, respectively). The magnetic resonance imaging (MRI) results indicated that the peripheral edema index (EI), enhancement percentage (EP), and the maximum diameter of the tumor in the high-grade group were significantly higher than those in the low-grade group (P<0.05, P<0.01, and P<0.05). Moreover, the expression of VEGF and MMP-9 was positively correlated with EI, EP and the maximum diameter of the tumor (P<0.05). Therefore, VEGF and MMP-9 expression were correlated to the invasion of glioma. The association of their expression levels with EI, EP and the maximum tumor diameter indicates that these markers may be used to estimate tumor malignancy for future clinical diagnosis and treatment.
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VEGF and MMP-9 are known to be important in invasion in the case of many human cancer cells.
“VEGF and MMP-9 are known to be important in invasion in the case of many human cancer cells (39).”
From Tumor suppressor PDCD4 inhibits NF-κB-dependent transcription in human glioblastoma cells by direct interaction with p65 (2014) · cites this paper as [39]
The Discussion (page unavailable) describes how VEGF and MMP-9 contribute to tumor invasion and identifies their expression as an indicator of glioma invasion. The study examines cerebral gliomas, however, and does not establish their importance across many kinds of human cancer cells. (LLM, conf=0.83)
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Cites
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α
Arany, Z., Foo, S.-Y., Ma, Y., Ruas, J. L., Bommi-Reddy, A., Girnun, G., Cooper, M., Laznik, D., Chinsomboon, J., Rangwala, S. M., et al. (2008) · Nature · doi:10.1038/nature06613 · Cited by 1,054 · see citing works
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Research works printed but not linked: 2
- Diamandis EP, Fritsche HA, Lilja H, Daniel WC and Schwartz MK (eds.): Tumor Markers: Physiology, Pathobiology, Technology, and Clinical Applications. AACC press, Washington DC, p17, 2002.
- Langer A: A systematic review of PET and PET/CT in oncology: a way to personalize cancer treatment in a cost-effective manner? BMC Health Serv Res 10: 283-299, 2010.
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Hwang, S.-K., Baker, A. R., Young, M. R., & Colburn, N. H. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu008 · Cited by 49 · see citing works
- Authors
- LIU, Y., ZHOU, Y., ZHANG, X.-S., & SHEN, B.-Z.
- Affiliations
- Harbin Medical University (CN)
- ORCID
- ZHOU, YANG
- Venue
- Oncology Letters
- Publisher
- Spandidos Publications
- Published
- 2011-08-17
- Volume
- 2
- Issue
- 6
- Pages
- 1171-1175
- ISSN
- 1792-1074 (ISSN-L)
- 1792-1082
- PMC
- PMC3406497
- OpenAlex
- W2133934124
- Cited by
- 21
- References
- 1
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Oncology Letters (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- brain glioma, vascular endothelial growth factor, MMP-9, tumor invasion, tumor enhancement, tumor size, magnetic resonance imaging, tumor malignancy markers
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