Tumor metabolic reprogramming in lung cancer progression (Review)
Open accessAbstract
Metabolic reprogramming is an important characteristic of tumor cells. Tumor cells reprogram their metabolic pathways to meet the material, energy and redox force needs for rapid proliferation. Metabolic reprogramming changes the level or type of specific metabolites inside and outside cells, and promotes tumor growth by affecting gene expression, cell state and the tumor microenvironment. Glucose metabolism, glutamine metabolism and lipid metabolism are significant metabolic pathways in tumors. Targeting metabolic reprogramming can significantly inhibit tumor growth and induce apoptosis. Metabolic reprogramming also plays an important role in maintaining the growth advantage of tumor cells and enhancing the chemotherapy tolerance of lung cancer. This review summarizes abnormal changes in the metabolism of glucose, fat and amino acids in lung cancer, and the underlying molecular mechanism, with the aim of providing novel ideas for the prevention, early diagnosis and treatment of lung cancer.
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There are ongoing efforts to utilize metabolic reprogramming in NSCLC as a therapeutic opportunity.
“There are a lot of ongoing efforts to utilize the process of metabolic reprogramming in Non-Small Cell Lung Cancer (NSCLC) as a therapeutic opportunity [21,22,23,24].”
From 20-Hydroxyecdysone Confers Antioxidant and Antineoplastic Properties in Human Non-Small Cell Lung Cancer Cells (2023) · cites this paper as [22]
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References 105 · Cited by 52
- Authors
- Li, X., Liu, M., Liu, H., & Chen, J.
- Affiliations
- Tianjin Medical University General Hospital (CN)
- Corresponding author
- Liu, Hongyu
- Chen, Jun
- Venue
- Oncology Letters
- Publisher
- Spandidos Publications
- Published
- 2022-06-28
- Volume
- 24
- Issue
- 2
- Pages
- 287-287
- ISSN
- 1792-1074 (ISSN-L)
- 1792-1082
- PMC
- PMC9260716
- OpenAlex
- W4283700577
- Cited by
- 52
- References
- 105
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 13 · 2023: 10 · 2022: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Oncology Letters (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- tumor metabolic reprogramming, lung cancer progression, glucose metabolism, glutamine metabolism, lipid metabolism, amino acid metabolism, tumor microenvironment, chemoresistance, apoptosis, tumor growth
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