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Frequent Homozygous Deletion of p16/CDKN2A Gene in Malignant Gliomas of Iranian Patients
Abstract
Homozygous deletion is the main mechanism of CDKN2A gene inactivation in malignant gliomas. However different frequencies were reported for its deletion. In order to find the homozygous deletion frequency among Iranian patients, we have analyzed the status of CDKN2A gene in 40 malignant gliomas and examined their lalpha and 2 exons by comparative multiplex Polymerase Chain Reaction (PCR), using D9S171 chromosomal marker as an internal control. We found homozygous deletion in 6 out of 7 cases (85.7%) of anaplastic astrocytomas and 20 out of 33 cases (60.6%) of glioblastoma multiforme, in total 26 out of 40 cases (65%) of malignant gliomas. We also found that CDKN2A deleted patients were younger than CDKN2A non-deleted patients and that exon 2 was deleted more than exon 1alpha.
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“These deletions are more commonly found in younger GBM patients [35].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [35]
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- Iwata, 1991, Mixed outbreak of Bordetella pertussis and Bordetella parapertussis in an apartment house., Dev. Biol. Stand., 73, 333
Cited by
The p53 Pathway in Glioblastoma
Zhang, Y., Dube, C., Gibert, M., Cruickshanks, N., Wang, B., Coughlan, M., Yang, Y., Setiady, I., Deveau, C., Saoud, K., et al. (2018) · Cancers · doi:10.3390/cancers10090297 · Cited by 440
Metadata
- Authors
- Dilmaghani, M., ., R. A., ., M. F., & ., P. D.
- Affiliations
- Iran University of Medical Sciences (IR)
- Venue
- Pakistan Journal of Biological Sciences
- Publisher
- Science Alert
- Published
- 2007-11-15
- Volume
- 10
- Issue
- 23
- Pages
- 4246-4250
- ISSN
- 1028-8880 (ISSN-L)
- OpenAlex
- W2034737494
- Cited by
- 10
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pakistan Journal of Biological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- CDKN2A, p16, homozygous deletion, high-grade glioma, glioblastoma, anaplastic astrocytoma, tumor suppressor inactivation, exon 2 deletion, Iranian patients, age at diagnosis
- MeSH terms
- Adolescent, Adult, Aged, Brain Neoplasms, Female, Glioma, Homozygote, Humans, Iran, Male, Middle Aged, Polymerase Chain Reaction, Gene Deletion, Genes, p16
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- CoChat. (2026). Citation check: Frequent Homozygous Deletion of p16/CDKN2A Gene in Malignant Gliomas of Iranian Patients. https://app.cochat.ai/papers/10.3923/pjbs.2007.4246.4250
- The paper
- Dilmaghani, M., ., R. A., ., M. F., & ., P. D. (2007). Frequent Homozygous Deletion of p16/CDKN2A Gene in Malignant Gliomas of Iranian Patients. Pakistan Journal of Biological Sciences. https://doi.org/10.3923/pjbs.2007.4246.4250
