A Technique for Retinal Pigment Epithelium Transplantation for Age-Related Macular Degeneration Secondary to Extensive Subfoveal Scarring
Abstract
ABSTRACT We describe the surgical excision of submacular scar in end-stage age-related macular degeneration and transplantation of autologous and homologous retinal pigment epithelial (RPE) cells. The technique involves the preparation of a large retinal flap encompassing the macula and the arcades, removal of the submacular scar, and replacement of the RPE cells, using either an autologous pedido graft or homologous RPE cells and Bruch's membrane. Fourteen months following the procedure, visual acuity in a patient with a pedicle graft had improved from counts fingers to 20/400 and the patient fixated over the transplanted RPE cells. After 10 months, a homologous graft in a second patient had become encapsulated with a fine subretinal membrane without neovascular tissue; visual acuity had not improved. No intraoperative or postoperative complications resulting from the surgery occurred in either patient.
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Clinical trials using allogenic RPE cells for the treatment of AMD two decades ago were all met with graft rejection.
“clinical trials conducted using allogenic RPE cells for the treatment of AMD, 2 decades ago, were all met with graft rejection (38–42).”
From Subretinal therapy: technological solutions to surgical and immunological challenges (2022) · cites this paper as [41]
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References 20 · Cited by 227
- Authors
- Peyman, G. A., Blinder, K. J., Paris, C. L., Alturki, W., Nelson, N. C., & Desai, U.
- Affiliations
- Louisiana State University (US)
- ORCID
- Blinder, Kevin J
- Venue
- Ophthalmic Surgery, Lasers and Imaging Retina
- Publisher
- SLACK, Inc.
- Published
- 1991-02
- Volume
- 22
- Issue
- 2
- Pages
- 102-108
- ISSN
- 1542-8877 (ISSN-L)
- 2325-8160
- 2325-8179
- OpenAlex
- W2418423387
- Cited by
- 227
- References
- 20
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 10 · 2019: 5 · 2018: 10 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 6 · 2013: 10 · 2012: 10
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ophthalmic surgery, lasers & imaging retina (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey007541-02)
- National Eye Institute (EY-02377, P30EY002377, EY07541)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- retinal pigment epithelium transplantation, age-related macular degeneration, Bruch's membrane, visual acuity outcomes
- MeSH terms
- Aged, Aged, 80 and over, Cicatrix, Female, Humans, Macular Degeneration, Methods, Pigment Epithelium of Eye, Surgical Flaps, Visual Acuity
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