Cited by 243Pharmacology and Obesity TreatmentObesity, Physical Activity, DietBariatric Surgery and Outcomes

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Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials

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Johansson, Kari, Neovius, Martin, Hemmingsson, Erik·2014·The American Journal of Clinical Nutrition

DOI 10.3945/ajcn.113.070052PMC PMC3862452

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Abstract

Background: Weight-loss maintenance remains a major challenge in obesity treatment. Objective: The objective was to evaluate the effects of anti-obesity drugs, diet, or exercise on weight-loss maintenance after an initial very-low-calorie diet (VLCD)/low-calorie diet (LCD) period (<1000 kcal/d). Design: We conducted a systematic review by using MEDLINE, the Cochrane Controlled Trial Register, and EMBASE from January 1981 to February 2013. We included randomized controlled trials that evaluated weight-loss maintenance strategies after a VLCD/LCD period. Two authors performed independent data extraction by using a predefined data template. All pooled analyses were based on random-effects models. Results: Twenty studies with a total of 27 intervention arms and 3017 participants were included with the following treatment categories: anti-obesity drugs (3 arms; n = 658), meal replacements (4 arms; n = 322), high-protein diets (6 arms; n = 865), dietary supplements (6 arms; n = 261), other diets (3 arms; n = 564), and exercise (5 arms; n = 347). During the VLCD/LCD period, the pooled mean weight change was −12.3 kg (median duration: 8 wk; range 3–16 wk). Compared with controls, anti-obesity drugs improved weight-loss maintenance by 3.5 kg [95% CI: 1.5, 5.5 kg; median duration: 18 mo (12–36 mo)], meal replacements by 3.9 kg [95% CI: 2.8, 5.0 kg; median duration: 12 mo (10–26 mo)], and high-protein diets by 1.5 kg [95% CI: 0.8, 2.1 kg; median duration: 5 mo (3–12 mo)]. Exercise [0.8 kg; 95% CI: −1.2, 2.8 kg; median duration: 10 mo (6–12 mo)] and dietary supplements [0.0 kg; 95% CI: −1.4, 1.4 kg; median duration: 3 mo (3–14 mo)] did not significantly improve weight-loss maintenance compared with control. Conclusion: Anti-obesity drugs, meal replacements, and high-protein diets were associated with improved weight-loss maintenance after a VLCD/LCD period, whereas no significant improvements were seen for dietary supplements and exercise.

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Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
A within-trial cost-effectiveness analysis of primary care referral to a commercial provider for weight loss treatment, relative to standard care—an international randomised controlled trial
Fuller, N. R., Colagiuri, S., SCHOFIELD, D. J., Olson, A. D., Shrestha, R. N., Holzapfel, C., Wolfenstetter, S. B., Holle, R., Ahern, A. L., Hauner, H., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.139 · Cited by 2,127
Long-term persistence of hormonal adaptations to weight loss
Sumithran, P., Prendergast, L. A., Delbridge, E., Purcell, K., Shulkes, A., Kriketos, A., & Proietto, J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1105816 · Cited by 1,449
Long-term weight-loss maintenance: a meta-analysis of US studies
Anderson, J. W., Konz, E. C., Frederich, R. C., & Wood, C. L. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.5.579 · Cited by 1,351
Who succeeds in maintaining weight loss? A conceptual review of factors associated with weight loss maintenance and weight regain
Elfhag, K., & Rössner, S. (2005) · Obesity Reviews · doi:10.1111/j.1467-789x.2005.00170.x · Cited by 1,343 · cited 1×
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Background
A descriptive study of individuals successful at long-term maintenance of substantial weight loss
Klem, M., Wing, R., McGuire, M., Seagle, H., & Hill, J. (1997) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.239 · Cited by 1,060
Discrepancy between self-reported and actual caloric intake and exercise in obese subjects
Lichtman, S. W., Pisarska, K., Berman, E. R., Pestone, M., Dowling, H., Offenbacher, E., Weisel, H., Heshka, S., Matthews, D. E., & Heymsfield, S. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199212313272701 · Cited by 964
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Larsen, T. M., Dalskov, S.-M., van Baak, M., Jebb, S. A., Papadaki, A., Pfeiffer, A. F. H., Martinez, J. A., Handjieva-Darlenska, T., Kunešová, M., Pihlsgård, M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1007137 · Cited by 843

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Brosnahan, N., Hankey, C., Leeds, A., Leslie, W. S., Thom, G., Hutchison, L., Govan, L., Ross, H. M., & Lean, M. E. J. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.08.009 · Cited by 2
Body weight, diabetes incidence vascular events and survival 15 years after very low calorie diet in community medical clinics in the UK
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Review of Current Anti-Obesity Drugs in Obese Adults
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Short-term Effects of Supplementation with a Multi-ingredient Weight-loss Product on Weight Maintenance and Fat Oxidation in Obese Female with Weight Reduction: Preliminary Results
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Worm, N. (2018) · Ernährung & Medizin · doi:10.1055/a-0636-1743 · Cited by 2
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Popular diets – what is the evidence?
Hooper, B. (2014) · Nutrition Bulletin · doi:10.1111/nbu.12104 · Cited by 1
Eating Behavior Associated With Weight Regain after Dietary Intervention in Obese Female
Sakane, N. (2016) · Journal of Diabetes and Obesity · doi:10.15436/2376-0494.16.995 · Cited by 1
Dietary and Behavioural Interventions in the Management of Obesity
Grace, C., & Brown, A. C. (2019) · Springer eBooks · doi:10.1007/978-3-319-99817-6_55 · Cited by 1
Furthering Scientific Inquiry for Weight Loss Maintenance: Assessing the Psychological Processes Impacted by a Low intensity Technology-Assisted Intervention (NULevel Trial)
Joyal‐Desmarais, K., Rothman, A. J., Evans, E. H., Araújo‐Soares, V., & Sniehotta, F. F. (2024) · Annals of Behavioral Medicine · doi:10.1093/abm/kaae002 · Cited by 1
Bariatric Endocrinology and Very-Low-Calorie Meal Plans
González-Campoy, J. M. (2017) · Endocrine Practice · doi:10.4158/ep171842.co · Cited by 1
Building a Patient-Centered Weight Management Program: A Mixed Methods Project to Obtain Patients’ Information Needs and Ideas for Program Structure
Arnold, A. D., Holmes, E. R., & Rosenthal, M. (2019) · Pharmacy · doi:10.3390/pharmacy7040165 · Cited by 1
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Peccin, S. (2016) · International Journal of Nutrology · doi:10.1055/s-0040-1705273 · Cited by 1
Effect of Adipose Tissue-Derived Stem Cell Transplantation and Six Weeks of Aerobic Exercise on FNDC5 and Irisin Levels in Streptozotocin-Induced Diabetic Rats
nasiraey, M., Chashmi, A. J., & Hashemvarzi, S. A. (2020) · Medical Laboratory Journal · doi:10.52547/mlj.14.6.34 · Cited by 1
Rôle et adaptation de l'activité physique
Bellicha, A., Oppert, J., & Ciangura, C. (2021) · Elsevier eBooks · doi:10.1016/b978-2-294-76753-1.00078-3 · Cited by 1
Weight management in adults
Mete, R., Georgousopoulou, E. N., Mellor, D. D., Khoo, J. J. C., Cheong, M., Leeds, A., Allan, K., Avery, A., Hart, K., Muir, A., et al. (2017) · Wiley eBooks · doi:10.1002/9781118857991.ch4 · Cited by 2
Computing Obesity: Signal Processing and Machine Learning Applied to Predictive Modeling of Clinical Weight-Loss
Biwer, C. (2017) · Deep Blue (University of Michigan) · Cited by 1
Herbal extract lowers body‐weight in overweight humans
Roufogalis, B. D. (2014) · Focus on Alternative and Complementary Therapies · doi:10.1111/fct.12107

Authors: Johansson, K., Neovius, M., & Hemmingsson, E.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Johansson, Kari
ORCID: Johansson, Kari
Neovius, Martin
Hemmingsson, Erik
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2014-01
Volume: 99
Issue: 1
Pages: 14-23
ISSN: 0002-9165 (ISSN-L)
DOI: 10.3945/ajcn.113.070052
PMC: PMC3862452
OpenAlex: W2155231441
Semantic Scholar: 3c5db8e0c32c0f2f1fc771ec71ad517c918034ae
Cited by: 243
References: 47
Citations by year: 2026: 5 · 2025: 11 · 2024: 6 · 2023: 19 · 2022: 18 · 2021: 28 · 2020: 18 · 2019: 17 · 2018: 20 · 2017: 27 · 2016: 21 · 2015: 27 · 2014: 24
FWCI: 3.05
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3333 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords: weight loss maintenance, very low calorie diet, hypocaloric diet, anti-obesity drugs, meal replacement, high-protein diet, dietary supplements, physical activity, obesity treatment, weight regain
MeSH terms: Energy Intake, Feeding Behavior, Humans, Obesity, Weight Loss, Exercise, Randomized Controlled Trials as Topic, Databases, Factual, Treatment Outcome, Anti-Obesity Agents, Caloric Restriction, Meals

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Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials

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