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Cited by 8Gastrointestinal motility and disordersCardiovascular Syncope and Autonomic DisordersGastroesophageal reflux and treatments

Altered gastroesophageal motility in patients with idiopathic orthostatic hypotension

Thatcher, B. S., Achkar, E., Fouad, F. M., O'Donnell, J. K., Revta, R.·1987·Cleveland Clinic Journal of Medicine
DOI 10.3949/ccjm.54.2.77
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Abstract

Although a variety of neurologic and systemic disorders are associated with abnormal gastroesophageal motility, little is known of gut involvement in patients with idiopathic orthostatic hypotension. To assess upper gastrointestinal motility, five patients with idiopathic orthostatic hypotension underwent esophageal manometry and esophageal and gastric radionuclide transit studies. Three patients had abnormal esophageal manometric studies, and two had abnormal gastric transit. The esophageal emptying study was abnormal in one of two patients. These results and the diversity of findings suggest that the upper gastrointestinal tract is involved in idiopathic orthostatic hypotension, although further work is needed to delineate the extent and the site of the abnormality. Esophageal manometry and gastroesophageal transit studies provide a means of diagnosing patients with idiopathic orthostatic hypotension.

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  • Pure autonomic failure is a chronic neurogenic autonomic disorder in which gastrointestinal involvement may include constipation and other manifestations of dysmotility.

    “Pure autonomic failure (PAF) is a chronic neurogenic autonomic disorder in which gastrointestinal involvement may include constipation and other manifestations of dysmotility (Sakakibara et al., 2000; Thatcher et al., 1987; Yamanaka et al., 2006).”

    From Autonomic nervous system and gastrointestinal manifestations with an emphasis on gastric dysfunction (2026) · cites this paper as Thatcher et al., 1987

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Authors
Thatcher, B. S., Achkar, E., Fouad, F. M., O'Donnell, J. K., & Revta, R.
Affiliations
Cleveland Clinic (US)
Venue
Cleveland Clinic Journal of Medicine
Publisher
Cleveland Clinic Journal of Medicine
Published
1987-03-01
Volume
54
Issue
2
Pages
77-82
ISSN
  • 0891-1150 (ISSN-L)
  • 1939-2869
DOI
10.3949/ccjm.54.2.77
OpenAlex
W2323456404
Cited by
8
References
0
Citations by year
2026: 1 · 2021: 1 · 2019: 1 · 2014: 1
FWCI
0.42
Type
journal article
Language
en
Open access
closed
Locations
  • Cleveland Clinic Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Keywords
idiopathic orthostatic hypotension, esophageal motility, gastric emptying, esophageal emptying, esophageal manometry, autonomic dysfunction, upper gastrointestinal tract
MeSH terms
Aged, Autonomic Nervous System Diseases, Esophagus, Female, Gastrointestinal Motility, Humans, Hypotension, Orthostatic, Male, Manometry, Middle Aged, Peristalsis, Shy-Drager Syndrome

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