The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
IgA nephropathy: Update on pathogenesis and treatment
Open accessAbstract
The pathogenesis of immunoglobulin (Ig) A nephropathy is described through a "4-hit" model involving production of galactose-deficient IgA, production of autoantibodies to galactose-deficient IgA, and subsequent deposition of immune complexes in the kidney glomerulus. Diagnosis remains dependent on a kidney biopsy, often after hematuria or proteinuria is detected on urinalysis. The cornerstone of therapy still involves renin-angiotensin-aldosterone system inhibitors or corticosteroids; however, new therapies targeting key aspects of the pathogenesis of IgA nephropathy are being introduced.
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Citations
Cites
Intensive supportive care plus immunosuppression in IgA nephropathy
Rauen, T., Eitner, F., Fitzner, C., Sommerer, C., Zeier, M., Otte, B., Panzer, U., Peters, H., Benck, U., Mertens, P. R., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1415463 · Cited by 726
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Metadata
- Authors
- Ramsawak, S., Cohen, S., Linares, A., & Cavanaugh, C.
- Affiliations
- Cleveland Clinic (US)
- Cleveland Clinic Florida (US)
- Venue
- Cleveland Clinic Journal of Medicine
- Publisher
- Cleveland Clinic Journal of Medicine
- Published
- 2025-06
- Volume
- 92
- Issue
- 6
- Pages
- 373-383
- ISSN
- 0891-1150 (ISSN-L)
- 1939-2869
- OpenAlex
- W4410957514
- Cited by
- 23
- References
- 1
- Citations by year
- 2026: 20 · 2025: 3
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Cleveland Clinic Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Gilead Sciences
- Topics
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Keywords
- IgA nephropathy, pathogenesis, autoantibodies, immune complex deposition, glomerular deposition, renal biopsy, hematuria, proteinuria, renin-angiotensin-aldosterone system inhibitors, corticosteroids, new drugs
- MeSH terms
- Adrenal Cortex Hormones, Angiotensin-Converting Enzyme Inhibitors, Glomerulonephritis, IGA, Humans, Immunoglobulin A, Renin-Angiotensin System
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