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Essential oils from Egyptian aromatic plants as antioxidant and novel anticancer agents in human cancer cell lines
Open accessAbstract
Inhibitors of tumor growth using extracts from aromatic plants are rapidly emerging as important new drug candidates for cancer therapy. The cytotoxicity and in vitro anticancer evaluation of the essential oils from thyme, juniper and clove has been assessed against five different human cancer cell lines (liver HepG2, breast MCF-7, prostate PC3, colon HCT116 and lung A549). A GC/MS analysis revealed that α-pinene, thymol and eugenol are the major components of Egyptian juniper, thyme and clove oils with concentrations of 31.19%, 79.15% and 82.71%, respectively. Strong antioxidant profiles of all the oils are revealed in vitro by DPPH and β-carotene bleaching assays. The results showed that clove oil was similarly potent to the reference drug, doxorubicin in prostate, colon and lung cell lines. Thyme oil was more effective than the doxorubicin in breast and lung cell lines while juniper oil was more effective than the doxorubicin in all the tested cancer cell lines except prostate cancer. In conclusion, the essential oils from Egyptian aromatic plants can be used as good candidates for novel therapeutic strategies for cancer as they possess significant anticancer activity.
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Metadata
- Authors
- Ramadan, M. M., Ali, M. M., Ghanem, K. Z., & El-Ghorabe, A. H.
- Affiliations
- National Research Centre (EG)
- Jazan University (SA)
- Venue
- Grasas y Aceites
- Publisher
- Editorial CSIC
- Published
- 2015-06-30
- Volume
- 66
- Issue
- 2
- Pages
- e080
- ISSN
- 0017-3495 (ISSN-L)
- 1988-4214
- OpenAlex
- W2088849181
- Cited by
- 38
- References
- 33
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 12 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 1 · 2015: 2
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Grasas y Aceites (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Physical Sciences › Chemistry › Organic Chemistry › Phytochemical Studies and Bioactivities
- Keywords
- essential oils, aromatic plants, antioxidant activity, anticancer activity, thyme essential oil, juniper oil, clove oil, thymol, eugenol, α-pinene, human cancer cell lines, cytotoxicity, doxorubicin comparison, Egyptian medicinal plants
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