Role of Probiotics in Human Gut Microbiome-Associated Diseases
Open accessAbstract
Probiotics, including bacteria and yeast, are live microorganisms that have demonstrated beneficial effects on human health. Recently, probiotic bacteria are constantly being studied and their applications are also being considered in promising adjuvant treatments for various intestinal diseases. Clinical trials and in vivo experiments have extended our current understanding of the important roles that probiotics play in human gut microbiomeassociated diseases. It has been documented through many clinical trials that probiotics could shape the intestinal microbiota leading to potential control of multiple bowel diseases and promotion of overall wellness. In this review, we focused on the relationship between probiotics and the human gut microbiota and its roles in gut microbiome-associated diseases. Here, we also discuss future directions and research areas that need further elucidation in order to better understand the roles of probiotics in the treatment of intestinal diseases.
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Probiotics are capable of promoting homeostasis of the intestinal microbiota through mucin production, competition for pathogen adherence, inflammation control, pH change, cytokine production, as well as having immunomodulatory and anti-inflammatory properties, which results in a better healthy condition.
“In addition, in the scenario of diseases caused by changes in the intestinal microbiota, the use of probiotics stands out since the probiotics are capable of promoting homeostasis of the intestinal microbiota through mucin production, competition for pathogen adherence, inflammation control, pH change, cytokine production, as well as having immunomodulatory and anti-inflammatory properties, which”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [15]
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Experimental — accuracy not yet measuredOne of the main effects of prebiotics is to increase the relative abundance and activity of gut microbial taxa involved in the metabolism of complex carbohydrates into SCFAs.
“One of the main effect of prebiotics is to increase the relative abundance and activity of gut microbial taxa involved in the metabolism of complex carbohydrates into SCFAs [44].”
From Role of diet and its effects on the gut microbiome in the pathophysiology of mental disorders (2022) · cites this paper as [44]
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References 33 · Cited by 519
- Authors
- Kim, S.-K., Guevarra, R. B., Kim, Y.-T., Kwon, J., Kim, H., Cho, J. H., Kim, H. B., & Lee, J.-H.
- Affiliations
- Kyung Hee University (KR)
- Dankook University (KR)
- Corresponding author
- Kim, Hyeun Bum
- Lee, Ju-Hoon
- Venue
- Journal of Microbiology and Biotechnology
- Published
- 2019-09-28
- Volume
- 29
- Issue
- 9
- Pages
- 1335-1340
- ISSN
- 1017-7825 (ISSN-L)
- 1738-8872
- OpenAlex
- W2978939437
- Cited by
- 519
- References
- 33
- Citations by year
- 2026: 50 · 2025: 123 · 2024: 111 · 2023: 107 · 2022: 75 · 2021: 37 · 2020: 13 · 2019: 1 · 2017: 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kyung Hee University
- Ministry of Food and Drug Safety (19162MFDS037)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, gut microbiota, intestinal diseases, probiotic bacteria, probiotic yeast, gut microbiota modulation, adjuvant therapy, clinical trials
- MeSH terms
- Gastrointestinal Microbiome, Clinical Trials as Topic, Homeostasis, Humans, Intestinal Diseases, Probiotics, Dysbiosis
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