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Cited by 82Macrophage Migration Inhibitory FactorAsthma and respiratory diseasesAllergic Rhinitis and Sensitization

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Macrophage Migration Inhibitory Factor Homologs of Anisakis simplex Suppress Th2 Response in Allergic Airway Inflammation Model via CD4+CD25+Foxp3+ T Cell Recruitment

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Park, Sang Kyun, Cho, Min Kyoung, Park, Hye-Kyung, Lee, Keun Hee, Lee, Sun Joo, Choi, Seon Hee, Ock, Mee Sun, Jeong, Hae Jin, Lee, Moo Hyung, Yu, Hak Sun·2009·The Journal of Immunology
DOI 10.4049/jimmunol.0803533
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Abstract

We have cloned the macrophage migration inhibitory factor (MIF)-like protein (Anisakis simplex (As)-MIF) from larvae of the whale worm (Anisakis simplex third-stage larvae). Asthma was induced in the mice using OVA/alum, with or without various concentrations of rAs-MIF treatment before OVA/alum challenge. Treatment with rAs-MIF coupled with OVA/alum during the challenge period induced a complete inhibition of eosinophilia and goblet cell hyperplasia within the lung and profoundly ameliorated the development of lung hyperreactivity. Also, rAs-MIF was shown to reduce profoundly the quantity of Th2-related cytokines (IL-4, IL-5, and IL-13) in the bronchial alveolar lavage fluid and allergen-specific IgG2a in sera. IL-10 and TGF-β levels in the bronchoalveolar lavage fluid of the rAs-MIF-treated group were significantly higher than in the other groups. Additionally, CD4+CD25+Foxp3+ T cells (regulatory T) were recruited to the spleen and lungs of the rAs-MIF-treated mice, but this recruitment was inhibited by anti-rAs-MIF Ab.

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References 55 · Cited by 82

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Metadata

Authors
Park, S. K., Cho, M. K., Park, H.-K., Lee, K. H., Lee, S. J., Choi, S. H., Ock, M. S., Jeong, H. J., Lee, M. H., & Yu, H. S.
Affiliations
  • Department of Parasitology
  • Pusan National University Hospital (KR)
  • Kosin University (KR)
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2009-06-01
Volume
182
Issue
11
Pages
6907-6914
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.0803533
OpenAlex
W1570979420
Cited by
82
References
55
Citations by year
2026: 3 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 5
FWCI
2.73
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Division of Human Resource Development
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
Keywords
Anisakis simplex, allergic airway inflammation, asthma, Th2 immune response, regulatory T cells, Foxp3, eosinophilia, goblet cell hyperplasia, IL-10, TGF-beta, IL-4, IL-5, IL-13, anti-MIF antibody, third-stage larvae
MeSH terms
Animals, Asthma, Bronchoalveolar Lavage Fluid, Chemotaxis, Leukocyte, Disease Models, Animal, Inflammation, Lung, Macrophage Migration-Inhibitory Factors, Spleen, Cytokines, Anisakis, Th2 Cells, T-Lymphocytes, Regulatory, Mice

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