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Cited by 60T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmune Response and Inflammation

Analysis of γδ T Cell Functions in the Mouse

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Born, Willi K, Yin, Zhinan, Hahn, Youn-Soo, Sun, Deming, O’Brien, Rebecca L·2010·The Journal of Immunology
DOI 10.4049/jimmunol.0903679PMC PMC4476288
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Abstract

Mouse models of disease and injury have been invaluable in investigations of the functional role of γδ T cells. They show that γδ T cells engage in immune responses both early and late, that they can function both polyclonally and as peripherally selected clones, and that they can be effector cells and immune regulators. They also suggest that functional development of γδ T cells occurs stepwise in thymus and periphery, and that it is governed by γδ TCR-signaling and other signals. Finally, they indicate that γδ T cell functions often segregate with TCR-defined subsets, in contrast to conventional T cells. From the functional studies in mice and other animal models, γδ T cells emerge as a distinct lymphocyte population with a unique and broad functional repertoire, and with important roles in Ab responses, inflammation and tissue repair. They also are revealed as a potentially useful target for immune intervention.

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  • Dermal γδ T cells have a fetal thymic origin.

    “Since dermal γδ T cells have a fetal thymic origin [1]”

    From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [1]

    The ‘Early functional commitment in the thymus’ section (page unavailable) says γδ T cells develop in the thymus and discusses thymic differentiation of dendritic epidermal T cells. The ‘Clonal selection in the periphery’ section (page unavailable) likewise describes thymic selection of epidermal cells, not dermal cells. Neither passage establishes a fetal thymic origin for dermal γδ T cells. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • γδ T cells function in immunosurveillance, playing a significant role in innate immunity, autoimmunity, and allergic responses.

    “γδ T cells function in immunosurveillance playing a significant role in innate immunity, autoimmunity and allergic responses [1].”

    From The Transcription Factor PU.1 Regulates γδ T Cell Homeostasis (2011) · cites this paper as [1]

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Authors
Born, W. K., Yin, Z., Hahn, Y.-S., Sun, D., & O’Brien, R. L.
Affiliations
  • National Jewish Health (US)
  • Nankai University (CN)
  • Chungbuk National University (KR)
  • University of Southern California (US)
Corresponding author
Born, Willi K
ORCID
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2010-04
Volume
184
Issue
8
Pages
4055-4061
ISSN
  • 0022-1767 (ISSN-L)
  • 1550-6606
DOI
10.4049/jimmunol.0903679
PMC
PMC4476288
OpenAlex
W1518508674
Cited by
60
References
1
Citations by year
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FWCI
3.30
Type
journal article
Language
en
Open access
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations
  • The Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Natural Science Foundation of China (2007CB914801)
  • National Institutes of Health
  • National Key Research and Development Program of China (2007CB914801)
  • National Heart, Lung, and Blood Institute (HL-65410, R01HL065410)
  • National Eye Institute (R01EY017373, R01EY018827)
  • National Institute of Allergy and Infectious Diseases (AI44920, AI 063400, R01AI044920, R21AI063400, R01AI040611, AI-40611)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK067629)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
γδ T cells, T cell function, T cell development, thymus, T cell receptor signaling, immune regulation, effector cells, antibody response, inflammation, tissue repair, immune intervention, mouse models of human disease
MeSH terms
Animals, Cell Differentiation, Disease Models, Animal, Humans, Thymus Gland, Signal Transduction, T-Lymphocyte Subsets, Receptors, Antigen, T-Cell, gamma-delta, Receptors, Antigen, T-Cell, alpha-beta, Inflammation Mediators, Models, Animal, Mice

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