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Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
Open accessAbstract
Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this study, we provide a comprehensive analysis of IL-23 and its receptor in psoriasis and demonstrate its functional importance in a disease-relevant model system. The expression of IL-23 and its receptor was increased in the tissues of patients with psoriasis. Injection of a mAb specifically neutralizing human IL-23 showed IL-23–dependent inhibition of psoriasis development comparable to the use of anti-TNF blockers in a clinically relevant xenotransplant mouse model of psoriasis. Together, our results identify a critical functional role for IL-23 in psoriasis and provide the rationale for new treatment strategies in chronic epithelial inflammatory disorders.
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Citations
Cited by
Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,650
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014) · Nature reviews. Immunology · doi:10.1038/nri3707 · Cited by 1,585
Teng, M. W. L., Bowman, E. P., McElwee, J. J., Smyth, M. J., Casanova, J.-L., Cooper, A. M., & Cua, D. J. (2015) · Nature Medicine · doi:10.1038/nm.3895 · Cited by 873
The IL-23-IL-17 axis in inflammatory arthritis
Lubberts, E. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.53 · Cited by 442
Hou, Y., Zhu, L., Tian, H., Sun, H.-X., Wang, R., Zhang, L., & Zhao, Y. (2018) · Protein & Cell · doi:10.1007/s13238-018-0505-z · Cited by 179
Metadata
- Authors
- Tonel, G., Conrad, C., Laggner, U., Di Meglio, P., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J.-Z., Xin, H., Oldham, E., Kastelein, R., Nickoloff, B. J., & Nestle, F. O.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-11
- Volume
- 185
- Issue
- 10
- Pages
- 5688-5691
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1741681584
- Cited by
- 224
- References
- 0
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis. https://app.cochat.ai/papers/10.4049/jimmunol.1001538
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- Tonel, G., Conrad, C., Laggner, U., Di Meglio, P., Grys, K., McClanahan, T. K., Blumenschein, W. M., Qin, J.-Z., Xin, H., Oldham, E., Kastelein, R., Nickoloff, B. J., & Nestle, F. O. (2010). Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1001538
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
