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The Role of the Transcription Factor CREB in Immune Function

Wen, Andy Y, Sakamoto, Kathleen M, Miller, Lloyd S·2010·The Journal of Immunology
DOI 10.4049/jimmunol.1001829PMC PMC5519339
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Abstract

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function—a role that is continually being defined.

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Metadata

Authors
Wen, A. Y., Sakamoto, K. M., & Miller, L. S.
Affiliations
  • Division of Pediatric Critical Care, University of California Los Angeles , Los Angeles, CA, 90095
  • Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of California Los Angeles , Los Angeles, CA, 90095
  • Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, CA, 90095
Venue
The Journal of Immunology
Publisher
Oxford University Press (OUP)
Published
2010-12-01
Volume
185
Issue
11
Pages
6413-6419
ISSN
  • 0022-1767
  • 1550-6606
DOI
10.4049/jimmunol.1001829
PMC
PMC5519339
Cited by
790
References
2
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)

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