The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
The Drosophila Toll Signaling Pathway
Abstract
The identification of the Drosophila melanogaster Toll pathway cascade and the subsequent characterization of TLRs have reshaped our understanding of the immune system. Ever since, Drosophila NF-κB signaling has been actively studied. In flies, the Toll receptors are essential for embryonic development and immunity. In total, nine Toll receptors are encoded in the Drosophila genome, including the Toll pathway receptor Toll. The induction of the Toll pathway by Gram-positive bacteria or fungi leads to the activation of cellular immunity as well as the systemic production of certain antimicrobial peptides. The Toll receptor is activated when the proteolytically cleaved ligand Spatzle binds to the receptor, eventually leading to the activation of the NF-κB factors Dorsal-related immunity factor or Dorsal. In this study, we review the current literature on the Toll pathway and compare the Drosophila and mammalian NF-κB pathways.
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Cites
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Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239
The Two NF-κB Pathways Regulating Bacterial and WSSV Infection of Shrimp
Li, C., Wang, S., & He, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01785 · Cited by 230
Toll-like receptors in the depressed and suicide brain
Pandey, G. N., Rizavi, H. S., Ren, X., Bhaumik, R., & Dwivedi, Y. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.01.021 · Cited by 164
Swatting flies: modelling wound healing and inflammation in Drosophila
Razzell, W., Wood, W., & Martin, P. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.006825 · Cited by 92
Yorkie-Cactus (IκBα)-JNK axis promotes tumor growth and progression in Drosophila
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Metadata
- Authors
- Valanne, S., Wang, J.-H., & Rämet, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01
- Volume
- 186
- Issue
- 2
- Pages
- 649-656
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2116760607
- Cited by
- 894
- References
- 104
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- closed
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