The DOI matches its Crossref record.
The Significance of the Mast Cell Response to Bee Venom
Abstract
Local tissue mast cells were found to rapidly secrete their heparin-containing granules in a dose-related response to subcutaneous injection of relatively small amounts of bee venom. The shed granules formed complexes with cationic protein in vivo and these complexes were subsequently ingested by adjacent mononuclear cells. Addition of heparin to bee venom in vitro resulted in the formation of complexes with reduction in both cytolytic and lethal activities of the venom. It is suggested that mast cell granules may, during transfer from mast cells to phagocytic cells, sequester noxious cationic proteins of bee venom and that dermal mast cells may thus be strategically situated and uniquely adapted to serve as a local means of resistance to bee sting.
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“Early work by Higginbotham and colleagues suggested that mast cells might be able to diminish the toxicity of certain venoms by degranulating and releasing heparin in response to venom exposure [76, 77].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [77]
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Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Melittin Interaction with Sulfated Cell Surface Sugars
Klocek, G., & Seelig, J. (2008) · Biochemistry · doi:10.1021/bi702258z · Cited by 60
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Metadata
- Authors
- Higginbotham, R. D., & Karnella, S.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1971-01-01
- Volume
- 106
- Issue
- 1
- Pages
- 233-240
- ISSN
- 0022-1767
- 1550-6606
- Cited by
- 32
- References
- 0
- Language
- en
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