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Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance
Open accessAbstract
Human regulatory T cells (Treg) are essential for the maintenance of immune tolerance. However, the mechanisms they use to mediate suppression remain controversial. Although IL-35 has been shown to play an important role in Treg-mediated suppression in mice, recent studies have questioned its relevance in human Treg. In this study, we show that human Treg express and require IL-35 for maximal suppressive capacity. Substantial upregulation of EBI3 and IL12A, but not IL10 and TGFB, was observed in activated human Treg compared with conventional T cells (Tconv). Contact-independent Treg-mediated suppression was IL-35 dependent and did not require IL-10 or TGF-β. Lastly, human Treg-mediated suppression led to the conversion of the suppressed Tconv into iTr35 cells, an IL-35–induced Treg population, in an IL-35–dependent manner. Thus, IL-35 contributes to human Treg-mediated suppression, and its conversion of suppressed target Tconv into IL-35–induced Treg may contribute to infectious tolerance.
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Cited by
Interleukin-35 induces regulatory B cells that suppress autoimmune disease
Wang, R.-X., Yu, C.-R., Dambuza, I. M., Mahdi, R. M., Dolinska, M. B., Sergeev, Y. V., Wingfield, P. T., Kim, S.-H., & Egwuagu, C. E. (2014) · Nature Medicine · doi:10.1038/nm.3554 · Cited by 733
Suppression assays with human T regulatory cells: A technical guide
McMurchy, A. N., & Levings, M. K. (2012) · European Journal of Immunology · doi:10.1002/eji.201141651 · Cited by 147
Herzog, R. W., Kuteyeva, V., Saboungi, R., Terhorst, C., & Biswas, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00274 · Cited by 24
Metadata
- Authors
- Chaturvedi, V., Collison, L. W., Guy, C. S., Workman, C. J., & Vignali, D. A. A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06
- Volume
- 186
- Issue
- 12
- Pages
- 6661-6666
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2106910404
- Cited by
- 205
- References
- 0
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Chaturvedi, V., Collison, L. W., Guy, C. S., Workman, C. J., & Vignali, D. A. A. (2011). Cutting Edge: Human Regulatory T Cells Require IL-35 To Mediate Suppression and Infectious Tolerance. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1100315
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