The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the Dermis
Open accessAbstract
Dendritic epidermal T cells (DETCs) are a well-studied population of γδ T cells that play important roles in wound repair. In this study, we characterize a second major population of γδ T cells in the skin that is present in the dermis. In contrast to DETCs, these Vγ5-negative cells are IL-7RhiCCR6hi retinoic acid-related orphan receptor γt+ and are precommitted to IL-17 production. Dermal γδ T cells fail to reconstitute following irradiation and bone marrow transplantation unless the mice also receive a transfer of neonatal thymocytes. Real-time intravital imaging of CXCR6GFP/+ mouse skin reveals dermal γδ T cells migrate at ∼4 μm/min, whereas DETCs are immobile. Like their counterparts in peripheral lymph nodes, dermal γδ T cells rapidly produce IL-17 following exposure to IL-1β plus IL-23. We have characterized a major population of skin γδ T cells and propose that these cells are a key source of IL-17 in the early hours after skin infection.
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Cites
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Acosta-Rodriguez, E. V., Rivino, L., Geginat, J., Jarrossay, D., Gattorno, M., Lanzavecchia, A., Sallusto, F., & Napolitani, G. (2007) · Nature Immunology · doi:10.1038/ni1467 · Cited by 1,828
Fate mapping of IL-17-producing T cells in inflammatory responses
Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
Heilig, J. S., & Tonegawa, S. (1986) · Nature · doi:10.1038/322836a0 · Cited by 448
Unutmaz, D., Xiang, W., Sunshine, M. J., Campbell, J., Butcher, E., & Littman, D. R. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3284 · Cited by 217
Kagami, S., Rizzo, H. L., Kurtz, S. E., Miller, L. S., & Blauvelt, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001153 · Cited by 216 · cited 2×
“In summary, although several studies have identified a critical role for IL-17 in the protective response mounted in the early hours to days of cutaneous infections (4, 5, 12), the precise cellular source of this IL-17 was not defined (5, 12) or was suggested to be DETCs (4).”
Cited by
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
The emerging role of resident memory T cells in protective immunity and inflammatory disease
Park, C. O., & Kupper, T. S. (2015) · Nature Medicine · doi:10.1038/nm.3883 · Cited by 517
γδ T cells in homeostasis and host defence of epithelial barrier tissues
Nielsen, M. M., Witherden, D. A., & Havran, W. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.101 · Cited by 479
Kashem, S. W., Riedl, M. S., Yao, C., Honda, C. N., Vulchanova, L., & Kaplan, D. H. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.016 · Cited by 448
Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing
Nosbaum, A., Prevel, N., Truong, H.-A., Mehta, P., Ettinger, M., Scharschmidt, T. C., Ali, N. H., Pauli, M. L., Abbas, A. K., & Rosenblum, M. D. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502139 · Cited by 418
Metadata
- Authors
- Gray, E. E., Suzuki, K., & Cyster, J. G.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-06-01
- Volume
- 186
- Issue
- 11
- Pages
- 6091-6095
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1906543170
- Cited by
- 263
- References
- 5
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Gray, E. E., Suzuki, K., & Cyster, J. G. (2011). Cutting Edge: Identification of a Motile IL-17–Producing γδ T Cell Population in the Dermis. The Journal of Immunology. https://doi.org/10.4049/jimmunol.1100427
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