Aging Is Associated with an Increase in T Cells and Inflammatory Macrophages in Visceral Adipose Tissue
Open accessAbstract
Age-related adiposity has been linked to chronic inflammatory diseases in late life. To date, the studies on adipose tissue leukocytes and aging have not taken into account the heterogeneity of adipose tissue macrophages (ATMs), nor have they examined how age impacts other leukocytes such as T cells in fat. Therefore, we have performed a detailed examination of ATM subtypes in young and old mice using state of the art techniques. Our results demonstrate qualitative changes in ATMs with aging that generate a decrease in resident type 2 (M2) ATMs. The profile of ATMs in old fat shifts toward a proinflammatory environment with increased numbers of CD206−CD11c− (double-negative) ATMs. The mechanism of this aging-induced shift in the phenotypic profile of ATMs was found to be related to a decrease in peroxisome proliferator-activated receptor-γ expression in ATMs and alterations in chemokine/chemokine receptor expression profiles. Furthermore, we have revealed a profound and unexpected expansion of adipose tissue T cells in visceral fat with aging that includes a significant induction of regulatory T cells in fat. Our findings demonstrate a unique inflammatory cell signature in the physiologic context of aging adipose tissue that differs from those induced in setting of diet-induced obesity.
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Aged mice have more adipose tissue T cells than young mice, which can contribute to a proinflammatory environment in visceral fat.
“Concomitant with greater body fat percentage, aged mice also have more adipose tissue T cells (ATTs) than young mice, which can contribute to create a proinflammatory environment in visceral fat [29].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [29]
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References 64 · Cited by 328
- Authors
- Lumeng, C. N., Liu, J., Geletka, L., Delaney, C., Delproposto, J., Desai, A., Oatmen, K., Martinez-Santibanez, G., Julius, A., Garg, S., & Yung, R. L.
- Affiliations
- University of Michigan (US)
- Graduate Program in Cellular and Molecular Biology, University of Michigan , Ann Arbor, MI 48109
- Department of Internal Medicine, University of Michigan , Ann Arbor, MI 48109
- Corresponding author
- Geletka, Lynn
- Delproposto, Jennifer
- Oatmen, Kelsie
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-12
- Volume
- 187
- Issue
- 12
- Pages
- 6208-6216
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- PMC
- PMC3237772
- OpenAlex
- W2165678812
- Cited by
- 328
- References
- 64
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 37 · 2023: 29 · 2022: 28 · 2021: 38 · 2020: 30 · 2019: 17 · 2018: 19 · 2017: 18 · 2016: 31 · 2015: 10 · 2014: 6 · 2013: 11 · 2012: 10
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01ag020628-10)
- National Institute on Aging (R01-AG-020628, R01AG028268, P30AG013283, R56AG020628, AG‐013283, P30AG024824)
- National Institute of General Medical Sciences (T32GM007315)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK090262, K08DK078851)
- National Institute of Environmental Health Sciences (P30ES017885)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (P30AR048310, R01AR042525)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- aging, visceral adipose tissue, adipose tissue macrophages, T cells, regulatory T cells, M2 macrophages, PPARγ, chronic inflammation, macrophage heterogeneity
- MeSH terms
- Aging, Animals, Cell Separation, Inflammation, Leukocyte Count, Leukocytes, Mononuclear, Mice, Inbred C57BL, Monocytes, Spleen, Immunophenotyping, T-Lymphocyte Subsets, Cellular Senescence, Macrophages, Peritoneal, Lymphocyte Count, Intra-Abdominal Fat, Mice
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