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Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity
Abstract
A transplantable, murine reticulum cell sarcoma is described which exhibits the cytologic, adherence, and phagocytic properties of macrophages. It forms specific rosettes with erythrocytes in the presence of the corresponding anti-serum. The ascites cells mediate antibody-dependent cellular immunity as assayed by release of radioactivity from 51Cr-labeled erythrocytes. The contribution of contaminating host cells in the cytotoxic reaction was ruled out by growing the tumor in F1 mice and removing the host cells by anti-H2 serum and complement. The tumor cells have receptors for IgG2a and IgG2b immunoglobulins. The availability of a pure population of effector cells in the immune system allows study of the biochemical processes pursuant to lysis of foreign cells.
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Citations
Cited by
Role of hemolysin for the intracellular growth of Listeria monocytogenes.
Portnoy, D. A., Jacks, P. S., & Hinrichs, D. J. (1988) · The Journal of experimental medicine · doi:10.1084/jem.167.4.1459 · Cited by 871
Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
Wobus, C. E., Karst, S. M., Thackray, L. B., Chang, K.-O., Sosnovtsev, S. V., Belliot, G., Krug, A., Mackenzie, J. M., Green, K. Y., & Virgin, H. W. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020432 · Cited by 833
Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin
Brown, K. E., Guest, S. S., Smale, S. T., Hahm, K., Merkenschlager, M., & Fisher, A. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80472-9 · Cited by 801
Alpuche Aranda, C. M., Swanson, J. A., Loomis, W. P., & Miller, S. I. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10079 · Cited by 437
Lee, S. H., Starkey, P. M., & Gordon, S. (1985) · The Journal of experimental medicine · doi:10.1084/jem.161.3.475 · Cited by 422
Metadata
- Authors
- Ralph, P., Prichard, J., & Cohn, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1975-02-01
- Volume
- 114
- Issue
- 2_Part_2
- Pages
- 898-905
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1936480433
- Cited by
- 420
- References
- 0
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity. https://app.cochat.ai/papers/10.4049/jimmunol.114.2_part_2.898
- The paper
- Ralph, P., Prichard, J., & Cohn, M. (1975). Reticulum Cell Sarcoma: An Effector Cell in Antibody-Dependent Cell-Mediated Immunity. The Journal of Immunology. https://doi.org/10.4049/jimmunol.114.2_part_2.898
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.