Lymphopenia-driven homeostatic regulation of naive T cells in elderly and thymectomized young adults
Abstract
Reduced thymopoiesis and continuous mobilization of naive T cells into the effector–memory pool can lead to severe alterations of the naive T cell compartment. However, maintenance of the naive T cell population is essential to mount effective immune responses. Evidence of homeostatic regulation of naive T cells is currently debated in animal models. In humans, the situation remains unresolved, in particular with advanced age. In this study, we analyzed the CD4+ and CD8+ naive T cell compartments from elderly, young adults thymectomized during early childhood, and HIV-1–infected patients, which are characterized by T lymphocytopenia. We show a direct association between increased turnover and decreased frequency of naive T cells. Moreover, the IL-7–induced pathway was fully functional in naive T cells from elderly and young adults thymectomized during early childhood, who are characterized by elevated IL-7 plasma levels. Our findings support the establishment of homeostatic regulation of naive T cell proliferation in humans. This regulation is particularly active in lymphopenic hosts, such as elderly and thymectomized patients.
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Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant.
“Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant [332, 333].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [333]
Human T cell generation in adulthood depends on peripheral proliferation of naive T cells.
“T cell generation during human adult life depends on peripheral proliferation of naive T cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Sauce et al., 2012
Partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells.
“This setting of partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells [77, 78].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [78]
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References 52 · Cited by 82
- Authors
- Sauce, D., Larsen, M., Fastenackels, S., Roux, A., Gorochov, G., Katlama, C., Sidi, D., Sibony-Prat, J., & Appay, V.
- Affiliations
- Inserm (FR)
- Hôpital Necker-Enfants Malades (FR)
- Centre Hospitalier Intercommunal André Grégoire Montreuil (FR)
- Corresponding author
- Sauce, Delphine
- Larsen, Martin
- Roux, Antoine
- Gorochov, Guy
- Appay, Victor
- ORCID
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-12
- Volume
- 189
- Issue
- 12
- Pages
- 5541-5548
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2158968421
- Cited by
- 82
- References
- 52
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 6 · 2018: 11 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 2
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- naive T cells, homeostatic regulation, lymphopenia, thymectomy, aging, CD4+ T cells, CD8+ T cells, IL-7 signaling, T cell proliferation, HIV-1 infection, thymopoiesis, T lymphocytopenia
- MeSH terms
- Adult, Age Factors, Aged, Aged, 80 and over, Cell Differentiation, Female, Homeostasis, Humans, Immunologic Memory, Lymphopenia, Male, Middle Aged, Thymectomy, T-Lymphocyte Subsets, Young Adult
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