The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes
Abstract
This study reports the in vitro influence of morphine, dextromoramide, levomoramide, and methionine-enkephalin upon normal human T blood lymphocytes by using the active and total rosette tests. Morphine and dextromoramide inhibited the percentage of active T rosettes. This effect was completely reversed in the presence of naloxone, their specific antagonist. The specificity was further demonstrated by the absence of the effect of levomoramide, the inactive enantiomere, upon the rosette system. Methionine-enkephalin increased the percentage of active T rosettes. This effect was specifically inhibited by naloxone. These observations suggest that normal human blood T lymphocytes bear surface receptor-like structures for morphine, dextromoramide, and methionine-enkephalin. Such findings may provide a link between the central nervous system and the immune system.
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Cites
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485 · cited 1×
“The /s-receptors more sensitive to morphine would be prodominant in guinea-pig ileum whereas the 6 more sensitive to enkephalins would be predominant in the mouse vas deferens (9).”
BackgroundHughes, J. (1975) · Brain Research · doi:10.1016/0006-8993(75)90391-1 · Cited by 982
Opiate receptor in normal and drug altered brain function*
Snyder, S. H. (1975) · Nature · doi:10.1038/257185a0 · Cited by 183
Mackay, I. R., CARNEGIE, P. R., & Coates, A. S. (1973) · PubMed · Cited by 44
Antibodies to Thymocytes in Sera of Patients with Schizophrenia
Luria, E. A., & Domashneva, I. V. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.235 · Cited by 22
Cited by
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Hutchinson, M. R., Bland, S. T., Johnson, K. W., Rice, K. C., Maier, S. F., & Watkins, L. R. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.230 · Cited by 359
The role of opioid receptors in immune system function
Eisenstein, T. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02904 · Cited by 286
Levy, S., Herberman, R., Lippman, M., & d'Angelo, T. (1987) · Journal of Clinical Oncology · doi:10.1200/jco.1987.5.3.348 · Cited by 278
Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations
Eisenstein, T. K., & Hilburger, M. E. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00219-1 · Cited by 262
Metadata
- Authors
- Wybran, J., Appelboom, T., Famaey, J.-P., & Govaerts, A.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1979-09-01
- Volume
- 123
- Issue
- 3
- Pages
- 1068-1070
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2142459943
- Cited by
- 580
- References
- 5
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes. https://app.cochat.ai/papers/10.4049/jimmunol.123.3.1068
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- Wybran, J., Appelboom, T., Famaey, J.-P., & Govaerts, A. (1979). Suggestive Evidence for Receptors for Morphine and Methionine-Enkephalin on Normal Human Blood T Lymphocytes. The Journal of Immunology. https://doi.org/10.4049/jimmunol.123.3.1068
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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